ArticleDiabetologia2025
Early weight loss, diabetes remission and long-term trajectory after diagnosis of type 2 diabetes: a retrospective study.
Article in Diabetologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Weight-related changes in MRI-derived measures of body composition and liver steatosis: a large-scale analysis for obesity trial design.International journal of obesity (2005) · 2026Article
- Remission rate of type 2 diabetes mellitus following multidisciplinary management in the diabetes reversal clinic and its predictive factors: a real-world study.Frontiers in endocrinology · 2026Observational
- Weight Loss Strategies Associated With Type 2 Diabetes Duration: A Population-Based Optimal Intervention Window From the NHANES.Journal of diabetes research · 2026Article
- Leonurine ameliorates experimental type 2 diabetes through gut microbiota remodeling, enhanced butyrate production, and MPC2 activation to restore GLP-1 secretion.Frontiers in pharmacology · 2026Article
- Type 2 diabetes remission after initiation of GLP-1 receptor agonists: frequency, characteristics, and outcomes using multiple definitions in an observational study.The Lancet regional health. Europe · 2025Article
- Long-term time in target range for body mass index (BMI) and diabetes incidence: insights from CHARLS.Nutrition & diabetes · 2025Article
- The Clock is Still Ticking: Tirzepatide and the Myth of Halting the Natural History of Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- β-cell heterogeneity and molecular plasticity in type 2 diabetes: multi-omics perspectives and the role of gut microbiota.Frontiers in cell and developmental biology · 2025Review
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisWeight loss can improve glycaemic management in individuals with type 2 diabetes, but its long-term effects on remission, cardiovascular risk factors and complications remain unclear. We investigated clinical outcomes following non-interventional ≥10% body weight loss in people with newly diagnosed type 2 diabetes in a routine care setting.
methodsWe retrospectively analysed two cohorts of people with newly diagnosed type 2 diabetes. After exclusions, cohort 1 included 1934 individuals followed for up to 25 years; cohort 2 comprised 13,277 individuals followed for up to 10 years. Participants were categorised into two groups based on whether or not they lost at least 10% body weight. In a sensitivity analysis, a group of participants with intermediate weight loss (5% to <10%) was also considered. Outcomes included HbA
resultsParticipants (58% male) had a mean age of 62 years and a mean diabetes duration of <2 years at inclusion; mean baseline HbA CONCLUSIONS/
interpretationEarly weight loss of ≥10% in type 2 diabetes was associated with sustained glycaemic improvements, increasing by three to four times the rates of diabetes remission. Remission, in turn, more than weight loss was associated with a reduced risk of complications.
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