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ArticleEuropean journal of nuclear medicine and molecular imaging2025

Persistent somatostatin PET signs of inflammatory cells 4 to 5 months after acute myocarditis are linked to a poorer recovery of cardiac function.

Thomas Larive, Caroline Boursier, Marine Claudin, Jeanne Varlot, Laura Filippetti, Olivier Huttin, Véronique Roch, Laetitia Imbert, Matthieu Doyen, Antoine Fraix and 3 more

Registry-linked trialAbstract read
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03347760 (Monocentric Interventionnal Pilot Study Pilot Study Evaluating Somatostatin Receptor's PET Imaging to Detect Inflammatory Phases of Myocarditis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03347760 nacompletednot on this map

Monocentric Interventionnal Pilot Study Pilot Study Evaluating Somatostatin Receptor's PET Imaging to Detect Inflammatory Phases of Myocarditis

TypeinterventionalSponsorCentral Hospital, Nancy, FranceRan2020 to 2023Enrolled33ConditionsMyocarditisArmsDOTATOC-68Ga PET initial, DOTATOC-68Ga PET at 6 months, blood sample
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. JACC. Advances · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Thomas LariveDepartment of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, 54000, Nancy, France.
Caroline BoursierDepartment of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, 54000, Nancy, France.
Marine ClaudinDepartment of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, 54000, Nancy, France.
Jeanne VarlotDepartment of Cardiology, CHRU Nancy, 54000, Nancy, France.
Laura FilippettiDepartment of Cardiology, CHRU Nancy, 54000, Nancy, France.
Olivier HuttinDepartment of Cardiology, CHRU Nancy, 54000, Nancy, France.
Véronique RochDepartment of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, 54000, Nancy, France.
Laetitia ImbertDepartment of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, 54000, Nancy, France.
Matthieu DoyenUniversité de Lorraine, IADI, INSERM U1254, F-54000, Nancy, France.
Antoine FraixDepartment of Cardiology, CHRU Nancy, 54000, Nancy, France.
Damien MandryUniversité de Lorraine, IADI, INSERM U1254, F-54000, Nancy, France.
Elodie ChevalierDepartment of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, 54000, Nancy, France.
Pierre-Yves MarieDepartment of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, 54000, Nancy, France. py.marie@chru-nancy.fr.ORCID 0000-0001-7319-3737

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAcute Myocarditis (AM) was recently shown to be detected by the Somatostatin Positron Emission Tomography (PET) criterion of > 18 cm

methodsCardiac Magnetic Resonance (CMR) and [

resultsEleven AM patients (41%) still had > 18 cm

conclusionsSomatostatin PET monitoring of AM unveils numerous patients with signs of a persistent inflammatory cell infiltrate 4 to 5 months after acute myocarditis. This persistence is associated with poorer recovery of cardiac function and is seemingly due to active inflammation that is either more severe at baseline or continues to expand over the following months. TRIAL REGISTRATION NUMBER: NCT03347760 on clinicaltrials.gov. Registration date: 22-11-2017.

Indexed as

MyocarditisPositron-Emission TomographyRecovery of FunctionSomatostatinAcute DiseaseAdultFemaleHumansInflammationMaleOctreotideTime FactorsYoung AdultOctreotideSomatostatin[68 Ga]Ga-DOTA-TOCCMRMyocarditisPETSomatostatin receptor

Identifiers

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.