Evidence map›Paper›PMID 40119846›Full record

ArticleStress and health : journal of the International Society for the Investigation of Stress2025

Longitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men.

Robyn A Ellis, Theresa K Webber, Natalie C Noble, Sarah D Linnstaedt, Rebecca Hinrichs, Charis Wiltshire, Mariam H Reda, William Davie, Stacey L House, Francesca L Beaudoin and 31 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Stress and health : journal of the International Society for the Investigation of Stress, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Robyn A EllisMcLean Hospital, Belmont, Massachusetts, USA.
Theresa K WebberMcLean Hospital, Belmont, Massachusetts, USA.
Natalie C NobleMcLean Hospital, Belmont, Massachusetts, USA.
Sarah D LinnstaedtDepartment of Anesthesiology, Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Rebecca HinrichsDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Charis WiltshireDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.
Mariam H RedaUniversity of Michigan Medical School, Ann Arbor, Michigan, USA.
William DavieDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.
Stacey L HouseDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Francesca L BeaudoinDepartment of Epidemiology, Brown University, Providence, Rhode Island, USA.
Xinming AnDepartment of Anesthesiology, Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Thomas C NeylanDepartments of Psychiatry and Neurology, University of California San Francisco, San Francisco, California, USA.
Gari D CliffordDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia, USA.
Laura T GermineDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Scott L RauchDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
John P HaranDepartment of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Alan B StorrowDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Christopher LewandowskiDepartment of Emergency Medicine, Henry Ford Health System, Detroit, Michigan, USA.
Paul I MuseyDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Phyllis L HendryDepartment of Emergency Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida, USA.
Sophia SheikhDepartment of Emergency Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida, USA.
Brittany E PunchesDepartment of Emergency Medicine, Ohio State University College of Medicine, Columbus, Ohio, USA.
Jose L PascualDepartment of Surgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mark J SeamonPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Elizabeth M DatnerDepartment of Emergency Medicine, Jefferson Einstein Hospital, Jefferson Health, Philadelphia, Pennsylvania, USA.
Claire PearsonDepartment of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, Michigan, USA.
David A PeakDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Robert M DomeierDepartment of Emergency Medicine, Trinity Health-Ann Arbor, Ypsilanti, Michigan, USA.
Niels K RathlevDepartment of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, Massachusetts, USA.
Brian J O'NeilDepartment of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, Michigan, USA.
Paulina SergotDepartment of Emergency Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.
Leon D SanchezDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Steven E BruceDepartment of Psychological Sciences, University of Missouri - St. Louis, St. Louis, Missouri, USA.
Jutta JoormannDepartment of Psychology, Yale University, New Haven, Connecticut, USA.
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA.
Kerry J ResslerDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Karestan C KoenenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Samuel A McLeanDepartment of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Tanja JovanovicDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.
Antonia V SeligowskiDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.

Funding

Longitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8M
Extracellular vesicles as biomarkers of trauma exposure and PTSD riskR01MH129495 · NIMH · UNIVERSITY OF COLORADO DENVER · PI Tracy L Bale, Tanja Jovanovic · 2022 to 2026
$4.0M
Mobile Measures of Threat Sensitivity for Cross-sectional and Longitudinal AssessmentR01MH121617 · NIMH · MCLEAN HOSPITAL · PI GERMINE, LAURA THI · 2020 to 2025
$3.9M
MAYDAY FundNIMH NIH HHS R01 MH121617NIMH NIH HHS R01 MH129495NIMH NIH HHS U01 MH110925One MindUS Army
6 · The paper itself

Abstract

PTSD is more prevalent in women than men and associated with autonomic dysfunction. Higher oestradiol levels have been associated with decreased PTSD severity, however, the impact of oestradiol on autonomic function is not well characterised. We examined associations among peritraumatic oestradiol levels and autonomic function in the multi-site AURORA study. Participants (n = 283, 69.6% female) were recruited from the emergency department (ED) following trauma exposure. Skin conductance (SC) was measured during trauma recall at the ED. Oestradiol was assayed from blood collected at ED, 2-week and 6-month. Fear conditioning, including fear potentiated startle (FPS), was completed at 2-week and 6-month. In women, ED oestradiol was significantly positively associated with ED SC and FPS at 6-month. In men, significant negative correlations between ED oestradiol and SC were found. Among women in the study, peritraumatic oestradiol was positively associated with fear responding 6-month. Findings suggest that the protective effects of oestradiol on PTSD may depend on other factors, such as time since trauma. Additional research is needed to elucidate how peritraumatic oestradiol and autonomic function may interact to confer risk for PTSD.

Indexed as

Autonomic Nervous SystemEstradiolFearGalvanic Skin ResponseStress Disorders, Post-TraumaticAdultEmergency Service, HospitalFemaleHumansLongitudinal StudiesMaleMiddle AgedReflex, StartleSex FactorsYoung AdultEstradiolautonomic functionfear conditioninggenderPTSDtrauma

Identifiers

PMID40119846
PMCPMC11991665

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.