Observational studyJournal of the European Academy of Dermatology and Venereology : JEADV2025
Early termination does not negatively impact the outcome of adjuvant immunotherapy in melanoma.
Observational study in Journal of the European Academy of Dermatology and Venereology : JEADV, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Real-world treatment patterns in stage III and IV melanoma patients: insights from a global multi-center chart review study.Frontiers in immunology · 2026Article
- Early termination does not negatively impact the outcome of adjuvant immunotherapy in melanoma.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Observational
Corrections and comments
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Authors and funding
27 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdjuvant treatment with anti-PD1 antibodies has been shown to effectively reduce the risk of recurrence in patients with resected metastatic melanoma. Whether a full 12-month duration of treatment is needed to achieve full clinical benefit is not known. This study investigated the survival outcome depending on the duration of adjuvant anti-PD1 therapy.
methodsFrom the prospective multicentre real-world skin cancer registry ADOREG data of 620 patients who finished adjuvant treatment with nivolumab or pembrolizumab for AJCCv8 stage III/IV resected melanoma was analyzed. Recurrence-free survival (RFS) and overall survival (OS) were compared between patients with regular treatment duration (52 ± 4 weeks; n = 229) and no disease recurrence during therapy (A
resultsThe median duration of follow-up was 26.0 months [interquartile range (IQR) 18.0-34.0] in group A
conclusionsIn patients with resected metastatic melanoma, shorter treatment duration with anti-PD1 antibodies is not associated with a worse outcome.
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