Evidence map›Paper›PMID 40119604›Full record

ArticleJournal of the science of food and agriculture2025

Phenolic characterization and nutraceutical evaluation of by-products from different globe artichoke cultivars.

Giusy Rita Caponio, Mirco Vacca, Laura Scalvenzi, Alessandro Annunziato, Roccangelo Silletti, Claudia Ruta, Graziana Difonzo, Maria De Angelis, Giuseppe De Mastro

Abstract read
In one paragraph

Article in Journal of the science of food and agriculture, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giusy Rita Caponio *Department of Bioscience, Biotechnology and Environment, University of Bari Aldo Moro, Bari, Italy.ORCID https://orcid.org/0000-0001-5446-5776
Mirco Vacca *Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Laura ScalvenziDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Alessandro AnnunziatoDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Roccangelo SillettiDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Claudia RutaDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Graziana DifonzoDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.ORCID https://orcid.org/0000-0003-1770-4584
Maria De AngelisDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Giuseppe De MastroDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.

Funding

National Recovery and Resilience Plan (NRRP), Mission 4-"Education and Research", Component 2-"From Research to Business", Investment 1.4-"Strengthening research structures and creating R&D "national champions" on specific key enabling technologies (Agritech)", CUP: H93C22000440007, code: CN_00000022, as well as OnFoods, Project code PE00000003, Concession Decree No. 1550 of 11 October 2022 adopted by the Italian Ministry of University and Research, CUP H93C22000630001, Project title
6 · The paper itself

Abstract

backgroundThe globe artichoke (Cynara cardunculus var. scolymus L.) is extensively cultivated in the Mediterranean region, with Italy being a leading producer. Industrial processing of artichoke plants generates substantial amounts of residual materials, which are discarded annually. This accumulation of biowaste presents environmental challenges. However, these by-products remain rich in phytochemicals, such as dietary fibers, phenolic acids, sesquiterpene lactones, flavonoids, vitamins and minerals, similar to those found in the edible parts of the plant. The present study aimed to evaluate the potential of artichoke by-products by analyzing aqueous extracts (AEs) from seven cultivars, comprising two commercial hybrids and five local varieties, focusing on their phenolic content, antioxidant activity, and prebiotic potential.

resultsThe primary phenolic compounds identified in the AEs were hydroxycinnamates, notably 5-O-caffeoylquinic acid and 3,5-di-O-caffeoylquinic acid, and flavonoids, primarily apigenin-7-O-rutinoside, luteolin and luteolin-7-O-rutinoside. These bioactive compounds were more abundant in two of the five local varieties, with concentrations exceeding those in commercial hybrids by more than twofold. Local varieties consistently exhibited higher total phenolic content and greater antioxidant activity, as determined by the DPPH (i.e. 2,2-diphenyl-1-picrilyhydrazil) assay. Furthermore, local varieties demonstrated a remarkable prebiotic potential, supporting more robust probiotic cell growth and resulting in greater acidification compared to commercial hybrids.

conclusionThe findings highlight the potential for valorizing artichoke biowastes as dietary supplements. The rich functional and bioactive properties of these by-products, particularly in local varieties, offer promising applications in food-related industries. This approach not only leverages their nutritional benefits, but also addresses environmental concerns by valorizing biowaste. © 2025 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

Cynara scolymusDietary SupplementsPhenolsPlant ExtractsWaste ProductsAntioxidantsFlavonoidsPrebioticsAntioxidantsFlavonoidsPhenolsPlant ExtractsPrebioticsWaste Productsartichokebioactive compoundsby‐product valorizationpolyphenolsprebiotic activitysustainability

Identifiers

PMID40119604
PMCPMC12130365

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.