ArticleJournal of veterinary internal medicine
Use of Cyclophosphamide, Vincristine, Prednisolone and Vinblastine for the Treatment of Large Cell Lymphoma in Cats.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Successful treatment and long-term follow-up of a young cat with feline infectious peritonitis and renal lymphoma.Open veterinary journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThe standard chemotherapy treatment for large-cell lymphoma in cats is CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) or COP (cyclophosphamide, vincristine, and prednisolone) chemotherapy protocols. Substituting vinblastine for vincristine might have similar efficacy, with lower severity of gastrointestinal adverse events. HYPOTHESIS/
objectivesTo evaluate whether the addition of vinblastine to a low-dose vincristine COP protocol could reduce the frequency and severity of adverse gastrointestinal effects while maintaining or increasing efficacy. ANIMALS: Medical records of 41 cats with large-cell lymphoma treated with the modified COVP protocol at one veterinary referral institution.
methodsRetrospective case series study. All relevant clinical data were retrospectively collected. Median progression-free survival, disease-free interval, and survival time were calculated using the Kaplan-Meier Method. Differences between groups were analyzed using the log-rank test, and adverse events were graded using VCOG-CTCAE v2.
resultsProgression-free survival was 264 days (range, 6-1486 days), the disease-free interval was 812 days (range, 39-1486 days) and the median survival time for all cats was 412 days (range, 7-1772 days). Complete response was achieved in 59% of the cases, and partial response was observed in 17%. Cats that achieved CR lived significantly longer, 838 days (range, 81-1772 days) versus 143 days (range, 10-798 days; p = 0.0018). The COVP protocol was generally well tolerated, and the most common adverse effects were mild signs of gastrointestinal disease and hematological abnormalities that did not require a pause in treatment. Grade-1 vomiting was the most common (24%), followed by grade-2 (22%) and grade-1 reduced appetite (20%).
conclusionCats with lymphoma treated with COVP seem to achieve acceptable survival and response rates compared to traditional chemotherapy protocols.
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