Evidence map›Paper›PMID 40119546›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2025

Factors Affecting the Relationship Between Total and Unbound Bilirubin in Preterm and Term Infants.

Thomas Hegyi, Dalya Chefitz, Alan Weller, Andrew Huber, Mary Carayannopoulos, William Oh, Alan Kleinfeld

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thomas HegyiDivision of Neonatology, Department of Pediatrics, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.ORCID 0000-0001-9919-1043
Dalya ChefitzDivision of Neonatology, Department of Pediatrics, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.
Alan WellerDivision of Neonatology, Department of Pediatrics, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.
Andrew HuberFluoresprobe, Inc., San Diego, California, USA.
Mary CarayannopoulosDivision of Neonatology, Department of Pediatrics, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.
William OhDepartment of Pediatrics, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Alan KleinfeldFluoresprobe, Inc., San Diego, California, USA.

Funding

Device for measuring blood concentrations of unbound bilirubin in neonatesR44HD080412 · NICHD · FLUORESPROBE SCIENCES, LLC · PI KLEINFELD, ALAN MARC · 2014 to 2020
$4.2M
Unbound fatty acids, Intralipid and Unbound Bilirubin in Preterm InfantsR03HD077422 · NICHD · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI HEGYI, THOMAS · 2014 to 2015
$157k
NICHD NIH HHS R03 HD077422NICHD NIH HHS R44HD080412
6 · The paper itself

Abstract

aimNewborn infants universally experience jaundice, most of which is physiologic, but in some high-risk situations, it may lead to neurological dysfunction or death. Unbound bilirubin (Bf) may be the best predictor of bilirubin toxicity in this population. The goal of the study is to examine the relationship between total serum bilirubin (TSB) and Bf and the influencing factors.

methodsTo calculate the relationship of Bf to TSB, we created a ratio (R) Bf/TSB × 10

resultsThe population consisted of 170 term and 130 preterm infants. The R was 3.64 ± 1.08 (SD) in term and 15.18 ± 9.8 in preterm infants. Prematurity and high TSB that required phototherapy significantly increased R. Higher R-values were seen at higher Bf toxic threshold levels.

conclusionAn R-value can reflect the relationship between Bf and TSB. The values are greater in prematurity and in infants with high TSB, which requires phototherapy.

Indexed as

BilirubinInfant, PrematureJaundice, NeonatalFemaleHumansInfant, NewbornMalePhototherapyBilirubinhyperbilirubinemianewbornunbound bilirubin

Identifiers

PMID40119546
PMCPMC12258115

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.