ArticleBiomedical engineering online2025
New considerations in selecting donors for dental pulp stem cells: a pilot study.
Article in Biomedical engineering online, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Regenerative potential of Dental Pulp Stem Cells (DPSCs) in dental and periodontal tissue engineering: a systematic review of preclinical and clinical studies.BMC oral health · 2026Pooled it
- A bioactive composite of freeze-dried stem cells, porous microcarriers, and fibrinogen-thrombin gel for dental pulp tissue engineering.American journal of stem cells · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
background/purposeTissue engineering based on stem cell therapy necessitates a substantial quantity of high-quality stem cells. However, current sources face limitations, including narrow donor pools, compromised biological properties due to cryopreservation, and cellular senescence resulting from in vitro passaging and expansion. This study examines the impact of mild periodontitis on the biological performance of dental pulp stem cells (DPSCs) to explore the potential of broadening the donor pool for these cells. MATERIALS AND
methodsThe experiment included two variables: age and the presence of periodontitis. DPSCs were isolated from six healthy subjects and six patients with mild periodontitis. Healthy subjects were categorized into Groups A (28-32 years) and B (52-54 years), and patients with mild periodontitis were categorized into Groups C (31-33 years) and D (50-53 years). The analyses included cell morphology, proliferation rate, multilineage differentiation capacity, apoptosis, and surface marker expression.
resultNo significant differences in cell morphology, pluripotency, or senescence were observed between healthy controls and periodontitis patients across age groups. Additionally, data on proliferation, pluripotency, and senescence were not significantly different. In healthy subjects, increased age was correlated with more elongated, flattened, and broader cells, alongside greater heterogeneity and intercellular granules. The proliferation and differentiation capacities decreased, whereas the degree of apoptosis increased. Similar trends were noted in patients with periodontitis.
conclusionThe biological properties of DPSCs remain unchanged in teeth with mild periodontitis, providing valuable insights for addressing the shortage of DPSCs in tissue engineering. Teeth with mild periodontitis have the potential to be pulp stem cell donors.
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Registered trials
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