Evidence map›Paper›PMID 40119414›Full record

ArticleCancer imaging : the official publication of the International Cancer Imaging Society2025

Acinar cell carcinoma of the pancreas: can CT and MR features predict survival?

Monica Cheng, Nikita Consul, Ryan Chung, Carlos Fernandez- Del Castillo, Yasmin Hernandez-Barco, Avinash Kambadakone

Abstract read
PubMed Full text at PMC Publisher
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Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Imaging of pancreatic hepatoid adenocarcinoma: a scoping review.Quantitative imaging in medicine and surgery · 2026
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Monica ChengDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA. mcheng0@mgh.harvard.edu.
Nikita ConsulDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
Ryan ChungDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Carlos Fernandez- Del CastilloDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yasmin Hernandez-BarcoDepartment of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Avinash KambadakoneDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the CT and MRI features of pancreatic acinar cell carcinoma (pACC) and their association with patient outcome and survival.

methodsThis retrospective single-center study included 49 patients with pathology-proven pancreatic acinar cell carcinoma who underwent diagnostic imaging between August 1998 - September 2019. Two radiologists reviewed CT and MRI features independently. Survival was estimated using the Kaplan-Meier method, and Cox proportional-hazards regression model was used to identify factors associated with survival.

resultspACC tended to present as a solid (31/49, 63.3%) pancreatic head mass (26/49, 53.1%) with ill-defined margins (32/49, 65.3%) and median maximal diameter of 4.1 cm (IQR, 2.9-6.2). Majority of lesions were hypo- or isodense (38/49, 77.6%) compared to normal pancreatic parenchyma, with heterogenous (39/49, 79.6%) enhancement pattern. Biliary ductal dilatation was uncommon, with pancreatic ductal dilatation in 22.4% (11/49) and common bile duct dilatation in 14.3% (7/49). Intralesional calcifications were seen in 6.1% (3/49). Metastasis was present in 71.4% (35/49) of patients at the time of diagnosis. On MRI, 88.9% (16/18) demonstrated diffusion restriction and 59.1% (13/22) with heterogenous enhancement. On multivariate analysis, the imaging presence of T1 hyperintensity (p = 0.02), hypoattenuating necrotic components (p = 0.02), and splenic vein invasion (p = 0.04) were associated with worse survival.

conclusionPancreatic acinar cell carcinoma is a rare pancreatic neoplasm that often presents as a large ill-defined heterogeneously enhancing mass without biliary ductal dilation. T1 hyperintensity, presence of hypoattenuating necrotic components, and splenic vein invasion were independent predictors of survival.

Indexed as

Carcinoma, Acinar CellMagnetic Resonance ImagingPancreatic NeoplasmsTomography, X-Ray ComputedAdultAgedFemaleHumansMaleMiddle AgedPancreasPrognosisRetrospective StudiesAcinar cell carcinomaBiomarkerCT and MRI featuresPancreas

Identifiers

PMID40119414
PMCPMC11929164

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.