Evidence map›Paper›PMID 40119269›Full record

ArticleBMC neurology2025

Case report: Coexistence of optic neuritis and primary anti-PLA2R-positive membranous nephropathy.

Xi Wang, Yuping Zeng, Yuliang Zhao, Boyi Li, Jing Yang

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PubMed Full text at PMC Publisher
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Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Xi Wang *Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yuping Zeng *Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yuliang ZhaoDepartment of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, 610041, China.
Boyi LiDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Jing YangDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, China. jingyang_cc@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOptic neuritis (ON) is an inflammatory optic neuropathy characterized by acute vision loss. Primary anti-PLA2R-positive membranous nephropathy, an autoimmune disease, has been reported to be related to neurological diseases. However, the co-occurrence of ON and primary membranous nephropathy (PMN) has not been reported. CASE PRESENTATION: A 57-year-old male presented with acute bilateral vision loss. Laboratory tests indicated proteinuria, hypoalbuminemia, hyperlipidemia, and a significantly increased level of anti-phospholipase A2 receptor antibody (PLA2RAb). Orbital MRI revealed inflammatory changes in the posterior segments of both optic nerves. Following treatments with corticosteroids and immunosuppressants, there was a significant improvement in the patient's vision and proteinuria.

conclusionThis case suggests that early identification and intervention for multisystem autoimmune damages are crucial for improving patient prognosis.

Indexed as

AutoantibodiesGlomerulonephritis, MembranousOptic NeuritisReceptors, Phospholipase A2HumansMagnetic Resonance ImagingMaleMiddle AgedAutoantibodiesPLA2R1 protein, humanReceptors, Phospholipase A2Anti-phospholipase A2 receptor antibodyCase reportMembranous nephropathyOptic neuritis

Identifiers

PMID40119269
PMCPMC11929292

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