Evidence map›Paper›PMID 40119209›Full record

ArticleNeurosurgical review2025

Prediction of persistent incomplete occlusion of intracranial aneurysms treated with woven EndoBridge device.

Muhammed Amir Essibayi, Mohamed Sobhi Jabal, Hasan Jamil, Hamza Adel Salim, Basel Musmar, Nimer Adeeb, Mahmoud Dibas, Nicole M Cancelliere, Jose Danilo Bengzon, Oktay Algin and 75 more

Abstract readMulticenter Study
In one paragraph

Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

85 authors.

Muhammed Amir EssibayiDepartments of Neurological Surgery, Radiology, and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Mohamed Sobhi JabalDepartments of Radiology and Neurosurgery, Mayo Clinic, Rochester, MN, USA.
Hasan JamilDepartments of Neurological Surgery, Radiology, and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Hamza Adel SalimDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Basel MusmarDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, LA, USA.
Nimer AdeebDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, LA, USA.
Mahmoud DibasDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, LA, USA.
Nicole M CancelliereNeurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Jose Danilo BengzonNeurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Oktay AlginDepartment of Radiology, Medical Faculty, Ankara University, Ankara, Turkey.
Sherief GhozyDepartments of Radiology and Neurosurgery, Mayo Clinic, Rochester, MN, USA.
Sovann V LayDepartment of Neuroradiology, Centre Hospitalier de Toulouse, Toulouse, France.
Adrien GuenegoDepartment of Neuroradiology, Hôpital Universitaire Erasme, Brussels, Belgium.
Leonardo RenieriDepartment of Neuroradiology, Ospedale Careggi Di Firenze, Florence, Italy.
Joseph CarnevaleDepartment of Neurosurgery and Neuroradiology, Weill Cornell School of Medicine, New York Presbyterian Hospitaland , New York, NY, USA.
Guillaume SaliouDepartment of Neuroradiology, Centre Hospitalier Vaudois de Lausanne, Lausanne, Switzerland.
Panagiotis MastorakosDepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Kareem El NaamaniDepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Eimad ShotarDepartment of Neuroradiology, Hôpital Pitié-Salpêtrière, Paris, France.
Markus MöhlenbruchDepartment of Neuroradiology, Universitätsklinikum Heidelberg, Heidelberg, Germany.
Michael KralDepartment of Neurosurgery, Christian Doppler University Hospital & Institute of Neurointervention, Salzburg, Austria.
Charlotte ChungDepartments of Radiology & Neurosurgery, NYU Langone Health Center, New York, NY, USA.
Mohamed M SalemDepartment of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, PA, USA.
Ivan LylykDepartment of Neuroradiology, Clínica La Sagrada Familia, Buenos Aires, Argentina.
Paul M ForemanDepartment of Neurosurgery, Orlando Health Neuroscience and Rehabilitation Institute, Orlando, FL, USA.
Hamza ShaikhDepartment of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, PA, USA.
Vedran ŽupančićDepartment of Neuroradiology, Clinical Hospital Center 'Sisters of Mercy', Zagreb, Croatia.
Muhammad U HafeezDepartment of Neurosurgery, UTMB and Baylor School of Medicine, Houston, TX, USA.
Joshua CatapanoDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, USA.
Muhammad WaqasDepartment of Neurosurgery, State University of New York at Buffalo, Buffalo, NY, USA.
Muhammed Said BeslerDepartment of Radiology, Kahramanmaraş Necip Fazıl City Hospital, Kahramanmaraş, Türkiye.
Yasin Celal GunesDepartment of Radiology, Kırıkkale Yuksek Ihtisas Hospital, Kırıkkale, Türkiye.
James D RabinovNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Julian MaingardDepartment of Neuroradiology, Austin Health, Heidelberg, VIC, Australia.
Clemens M SchirmerDepartment of Neurosurgery and Radiology, Geisinger Hospital, Danville, PA, USA.
Mariangela PianoDepartment of Neuroradiology, Ospedale Niguarda Cà Granda, Milan, Italy.
Anna L KühnDepartment of Neuroradiology, UMass Memorial Hospital, Worcester, MA, USA.
Caterina MichelozziDepartment of Neuroradiology, Ospedale San Raffaele, Milan, Italy.
Robert M StarkeDepartment of Neurosurgery, University of Miami, Miami, FL, USA.
Ameer HassanDepartment of Neuroradiology, Valley Baptist Neuroscience Institute, Harlingen, TX, USA.
Mark OgilvieDeparments of Neurosurgery and Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Anh NguyenDepartment of Neuroradiology, Valley Baptist Neuroscience Institute, Harlingen, TX, USA.
Jesse JonesDeparments of Neurosurgery and Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Waleed BrinjikjiDepartments of Radiology and Neurosurgery, Mayo Clinic, Rochester, MN, USA.
Marie T NawkaDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Marios PsychogiosDepartment of Neuroradiology, University Hospital of Basel, Basel, Switzerland.
Christian UlfertDepartment of Neuroradiology, Universitätsklinikum Heidelberg, Heidelberg, Germany.
Bryan PukenasDepartment of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, PA, USA.
Jan-Karl BurkhardtDepartment of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, PA, USA.
Thien HuynhDepartments of Radiology and Neurosurgery, Mayo Clinic, Jacksonville, FL, USA.
Juan Carlos Martinez-GutierrezDepartment of Neuroradiology, University of Texas Health Science Center at Houston, Houston, TX, USA.
Sunil A ShethDepartment of Neuroradiology, University of Texas Health Science Center at Houston, Houston, TX, USA.
Diana SlawskiDepartment of Radiology, Division of Neuroimaging and Neurointervention, Stanford University School of Medicine, Stanford, CA, USA.
Rabih TawkDepartments of Radiology and Neurosurgery, Mayo Clinic, Jacksonville, FL, USA.
Benjamin PulliDepartment of Radiology, Division of Neuroimaging and Neurointervention, Stanford University School of Medicine, Stanford, CA, USA.
Boris LubiczDepartment of Neuroradiology, Hôpital Universitaire Erasme, Brussels, Belgium.
Pietro PanniDepartment of Neuroradiology, Ospedale Niguarda Cà Granda, Milan, Italy.
Ajit S PuriDepartment of Neuroradiology, UMass Memorial Hospital, Worcester, MA, USA.
Guglielmo PeroDepartment of Neuroradiology, Ospedale Niguarda Cà Granda, Milan, Italy.
Eytan RazDepartments of Radiology & Neurosurgery, NYU Langone Health Center, New York, NY, USA.
Christoph J GriessenauerDepartment of Neurosurgery, Christian Doppler University Hospital & Institute of Neurointervention, Salzburg, Austria.
Hamed AsadiDepartment of Neuroradiology, Austin Health, Heidelberg, VIC, Australia.
Adnan SiddiquiDepartment of Neurosurgery, State University of New York at Buffalo, Buffalo, NY, USA.
Elad I LevyDepartment of Neurosurgery, State University of New York at Buffalo, Buffalo, NY, USA.
Deepak KhatriDepartments of Neurological Surgery, Radiology, and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Neil HaranhalliDepartments of Neurological Surgery, Radiology, and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Andrew F DucruetDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, USA.
Felipe C AlbuquerqueDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, USA.
Robert W RegenhardtNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Christopher J StapletonNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Peter KanDepartment of Neurosurgery, UTMB and Baylor School of Medicine, Houston, TX, USA.
Vladimir KalousekDepartment of Neuroradiology, Clinical Hospital Center 'Sisters of Mercy', Zagreb, Croatia.
Pedro LylykDepartment of Neuroradiology, Clínica La Sagrada Familia, Buenos Aires, Argentina.
Srikanth BodduDepartment of Neurosurgery and Neuroradiology, Weill Cornell School of Medicine, New York Presbyterian Hospitaland , New York, NY, USA.
Jared KnopmanDepartment of Neuroradiology, Centre Hospitalier Vaudois de Lausanne, Lausanne, Switzerland.
Stavropoula I TjoumakarisDepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Hugo H Cuellar-SaenzDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, LA, USA.
Pascal M JabbourDepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Frédéric ClarençonDepartment of Neuroradiology, Hôpital Pitié-Salpêtrière, Paris, France.
Nicola LimbucciDepartment of Neurosurgery and Neuroradiology, Weill Cornell School of Medicine, New York Presbyterian Hospitaland , New York, NY, USA.
Vitor Mendes PereiraNeurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Aman B PatelNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
David J AltschulDepartments of Neurological Surgery, Radiology, and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA. daltschu@montefiore.org.
Adam A DmytriwNeurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
WorldWideWEB Consortium Collaborators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the Woven EndoBridge (WEB) device has transformed the treatment of wide-neck intracranial aneurysms, incomplete occlusion remains a significant challenge requiring better understanding of contributing factors. A retrospective analysis was conducted on multicenter data from patients who underwent WEB device treatment for intracranial aneurysms between January 2011 and December 2022. Using machine learning models, Cox regression, and time-stratified analyses, we evaluated factors associated with persistent incomplete occlusion, defined as non-improving Raymond-Roy Occlusion Classification grade 2 or 3 at final follow-up. Among 813 patients (607 with < 24 months follow-up, 206 with ≥ 24 months), machine learning analysis identified aneurysm height, Acom location, neck diameter, and pretreatment mRS as predictors of persistent incomplete occlusion. On Cox regression. larger aneurysm neck diameter (HR 1.13, 95% CI 1.01-1.27, p = 0.027) and height (HR 1.14, 95% CI 1.02-1.26, p = 0.017), and radial access (HR 2.68, 95% CI 1.76-4.07, p < 0.001) increased, while posterior circulation location (HR 0.56, 95% CI 0.37-0.84, p = 0.005) decreased the risk of persistent incomplete occlusion. Time-stratified analysis revealed that in short-term follow-up (< 24 months), larger aneurysm neck diameter (OR 1.28, 95% CI 1.08-1.52, p = 0.004) increased the risk of incomplete occlusion. In long-term follow-up (≥ 24 months), smoking (OR 2.69, 95% CI 1.04-7.00, p = 0.04), higher pre-treatment mRS (OR 1.78, 95% CI 1.15-2.76, p = 0.009), and immediate flow stagnation (OR 0.33, 95% CI 0.11-0.96, p = 0.04) increased, while older age (OR 0.94, 95% CI 0.90-0.98, p = 0.002) and WEB-DL (OR 0.06, p < 0.001) and SLS devices (OR 0.02, p = 0.003) decreased the risk of persistent incomplete occlusion. Aneurysm characteristics and device type significantly influence long-term WEB treatment outcomes.

Indexed as

Embolization, TherapeuticEndovascular ProceduresIntracranial AneurysmAdultAgedFemaleHumansMachine LearningMaleMiddle AgedRetrospective StudiesTreatment OutcomeAneurysmsBrainFollow-upIncomplete occlusionWoven EndoBridge

Identifiers

PMID40119209
PMCPMC11928387

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