SynthesisNature aging2025
A systematic review with a Burden of Proof meta-analysis of health effects of long-term ambient fine particulate matter (PM
Abstract readSystematic ReviewMeta-Analysis
In one paragraph
Synthesis in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic and environmental risk factors of asthma: a narrative review.Frontiers in immunology · 2026Pooled it
- Multimorbidity patterns and cognitive trajectories in older adults: functional, behavioral, and environmental pathways-a longitudinal analysis of CHARLS.Research square · 2026Article
- Identification of chemicals targeting dementia genes and pathways in the Comparative Toxicogenomics Database.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Aging in a highly polluted world: challenges and solutions to prevent Alzheimer's disease.Archives of toxicology · 2026Review
- Association between residential physical environmental exposures and multidimensional successful ageing in the UK biobank.BMC public health · 2026Article
- The policy exposome of dementia: Gaps, opportunities, and research agenda.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- The sex-specific association between long-term PM2.5 exposure and incident dementia in community-dwelling older adults in Australia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Racial and ethnic differences in the impact of air pollution on the risk of Alzheimer's disease and related dementias in the Multiethnic Cohort Study.Environment international · 2026Article
- Sharing common measures of the environment across continents: challenges and opportunities for global studies of aging.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Artificial intelligence and machine learning for precision prevention of cognitive decline: integrating multimodal biomarkers, lifestyle interventions, and natural medicines from prediction to clinical practice.Frontiers in aging neuroscience · 2026Review
- Identification of chemicals targeting dementia genes and pathways in the Comparative Toxicogenomics Database.bioRxiv : the preprint server for biology · 2025Article
- Environmental Factors and Risk of Early-Onset Dementia: A Population-Based Case-Control Study.Neuroepidemiology · 2025Article
- Environmental Stressors and Neuroinflammation: Linking Climate Change to Alzheimer's Disease.Current issues in molecular biology · 2025Review
- Genistein Inhibits Fine-Dust-Induced Matrix Metalloproteinase-1 in Human Keratinocytes.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Environmental toxins in neurodegeneration - a narrative review.Neurological research and practice · 2025Review
- Ambient Air Pollution and the Severity of Alzheimer Disease Neuropathology.JAMA neurology · 2025Article
- Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.Lancet (London, England) · 2025Article
- The absolute and relative concentration-response patterns of exposure to ambient air pollutants and the risk of Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2025Article
- Age-sex differences in Alzheimer's and related dementias burden and risk factors in east and Southeast Asia: results from the 2021 GBD study.Frontiers in aging neuroscience · 2025Article
- Defining healthy longevity and dementia prevention campaigns have been tied to the ability to work.Journal of Alzheimer's disease reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Xinmei HuangInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0009-0002-9702-3649
Jaimie SteinmetzInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
Elizabeth K MarshInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
Aleksandr Y AravkinInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
Charlie AshbaughInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
Christopher J L MurrayInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
Fanghan YangInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
John S JiInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5002-118X
Peng ZhengInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
Reed J D SorensenInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
Sarah WozniakInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
Simon I HayInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-0611-7272
Susan A McLaughlinInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
Vanessa GarciaInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
Michael BrauerInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
Katrin BurkartInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA. katburk@uw.edu.ORCID http://orcid.org/0000-0001-6772-620X
Funding
Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) OPP1152504
Abstract
Previous studies have indicated increased dementia risk associated with fine particulate matter (PM
Indexed as
Air PollutantsAir PollutionDementiaEnvironmental ExposureParticulate MatterAgedHumansLongitudinal StudiesMaleAir PollutantsParticulate Matter
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.