Evidence map›Paper›PMID 40119165›Full record

ArticleScientific reports2025

Preliminary feasibility study on DTI to assess the early brain injury in germinal matrix-intraventricular hemorrhage rats.

Chi Qin, Chenxi Guo, Huixian Li, Ronghao Mu, Meiying Cheng, Haiyang Li, Xiang Feng, Bohao Zhang, Yue Li, Jian Jin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chi QinDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Chenxi GuoDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Huixian LiDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ronghao MuDepartment of Child Developmental Behavior, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Meiying ChengDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Haiyang LiDepartment of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiang FengMRSolutions Ltd., Guildford, Surrey, GU3 1LR, UK.
Bohao ZhangDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yue LiDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jian JinDepartment of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xin ZhaoDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China. zdsfyzx@zzu.edu.cn.
Xiaoan ZhangDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China. zxa@zzu.edu.cn.

Funding

The National Natural Science Foundation of China 82371929The National Natural Science Foundation of China 82472046The Postdoctoral Research Special Fund of the Third Affiliated Hospital of Zhengzhou University 2023080
6 · The paper itself

Abstract

To evaluate the feasibility and efficacy of diffusion tensor imaging (DTI) for detecting early brain microstructure alterations in germinal matrix-intraventricular hemorrhage (GMH-IVH) rat model. This study used a postnatal day 5 (PND 5) rat model of GMH-IVH. T2-weighted imaging and DTI were performed during acute (6 h and 24 h) and subacute (3d and 7d) phases after GMH-IVH. Four DTI parameters including fractional anisotropy (FA), mean diffusion (MD), axial diffusion (AD) and radial diffusion (RD) were collected in 9 specific brain regions to assess the brain microstructure alterations. Early and long-term neurological function tests were evaluated. Transcriptome sequencing analysis was also performed to investigate possible underlying mechanisms. Regional abnormalities after GMH-IVH were observed in T2-weighted images that showed significant hypointense in striatum region which close to the germinal matrix. DTI parameters also observed changes in striatum region in GMH-IVH. Alterations in other regions of brain including hippocampus, thalamus, external capsule and motor cortex also noted, which were associated with the abnormalities observed in behavioral experiments. Long-term behavioral tests show that compared to sham group, rats in GMH-IVH group caused abnormal motor function. In addition, at 24 h after GMH-IVH, transcriptome analysis results showed that the highly expressed differential genes encode hemoglobin components and down-regulate neurodevelopment-related pathways. DTI imaging allows the early assessment of neurological alteration in GMH-IVH rat pups, and providing great value in evaluating long-term behavioral deficits.

Indexed as

Brain InjuriesCerebral HemorrhageDiffusion Tensor ImagingAnimalsBrainDisease Models, AnimalFeasibility StudiesMaleRatsRats, Sprague-DawleyDiffusion tensor imageGerminal matrix-intraventricular hemorrhageMotor and cognitive impairmentPathological changes

Identifiers

PMID40119165
PMCPMC11928497

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