Evidence map›Paper›PMID 40119124›Full record

ArticleJournal of human genetics2025

Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women.

Tomoki Kawahara, Nobutoshi Nawa, Keiko Murakami, Toshihiro Tanaka, Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Masatsugu Orui and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Fulminant and Slowly Progressive Type 1 Diabetes Associated with Pregnancy.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Tomoki KawaharaDepartment of Public Health, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-9849-3880
Nobutoshi NawaDepartment of Public Health, Institute of Science Tokyo, Tokyo, Japan. nawa.ioe@tmd.ac.jp.ORCID http://orcid.org/0000-0001-6785-7867
Keiko MurakamiTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Toshihiro TanakaDepartment of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-6201-9784
Hisashi OhsetoGraduate School of Medicine, Tohoku University, Sendai, Japan.
Ippei TakahashiGraduate School of Medicine, Tohoku University, Sendai, Japan.
Akira NaritaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.ORCID http://orcid.org/0000-0002-9076-0710
Taku ObaraTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.ORCID http://orcid.org/0000-0002-3674-1674
Mami IshikuroTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Masatsugu OruiTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Aoi NodaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Genki ShinodaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Yuki NagataTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.ORCID http://orcid.org/0000-0002-7859-9661
Satoshi NagaieTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Soichi OgishimaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Junichi SugawaraTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Shigeo KureTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Kengo KinoshitaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.ORCID http://orcid.org/0000-0003-3453-2171
Atsushi HozawaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Nobuo FuseTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Gen TamiyaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.ORCID http://orcid.org/0000-0002-0597-415X
Wendy L BennettDivision of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
Margaret A TaubDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Pamela J SurkanDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Shinichi KuriyamaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.ORCID http://orcid.org/0000-0002-6445-0911
Takeo FujiwaraDepartment of Public Health, Institute of Science Tokyo, Tokyo, Japan.

Funding

Social and gene interactions to understand the risk of gestational diabetes mellitusR21HD101778 · NICHD · JOHNS HOPKINS UNIVERSITY · PI FUJIWARA, TAKEO, SURKAN, PAMELA J · 2021 to 2022
$396k
NICHD NIH HHS R21 HD101778
6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM) is common in Japanese women, posing serious risks to mothers and offspring. This study investigated the influence of maternal genotypes on the risk of GDM and examined how these genotypes modify the effects of psychological and dietary factors during pregnancy. We analyzed data from 20,399 women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort. Utilizing two customized SNP arrays for the Japanese population (Affymetrix Axiom Japonica Array v2 and NEO), we performed a meta-analysis to combine the datasets. Gene-environment interactions were assessed by modeling interaction terms between genome-wide significant single nucleotide polymorphisms (SNPs) and psychological and dietary factors. Our analysis identified two SNP variants, rs7643571 (p = 9.14 × 10

Indexed as

Diabetes, GestationalGene-Environment InteractionGenetic Predisposition to DiseaseAdultEast Asian PeopleFemaleGenome-Wide Association StudyGenotypeHumansJapanPolymorphism, Single NucleotidePregnancyRisk Factors

Identifiers

PMID40119124
PMCPMC12032887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.