Evidence map›Paper›PMID 40119096›Full record

ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2025

Impact of intraoperative desmopressin on postoperative urine output in adult cadaveric kidney transplantation: a single-centre retrospective cohort study.

Samhati Mondal, Catherine Wasylyshyn, Roumen Vesselinov, Miranda Gibbons, Chandrasekhar Bhati, Stephanie E Jones, Peter Rock, Megan G Anders

Abstract read
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In one paragraph

Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Abdominal Organ Transplantation: Noteworthy Literature in 2025.Seminars in cardiothoracic and vascular anesthesia · 2026
    Review
  2. In reply: Desmopressin in kidney transplantation: much ado about reduced urine output?Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025
    Article
  3. Desmopressin in kidney transplantation: much ado about reduced urine output?Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samhati MondalDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA. smondal@som.umaryland.edu.ORCID 0000-0002-0897-0998
Catherine WasylyshynOffice of Students Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Roumen VesselinovDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Miranda GibbonsDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Chandrasekhar BhatiDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Stephanie E JonesDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Peter RockDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Megan G AndersDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA.

Funding

Research Support, Non-US Gov’t
6 · The paper itself

Abstract

purposeDesmopressin, a synthetic analogue of vasopressin, is used to prevent uremic bleeding in patients undergoing kidney transplantation but can cause oliguria. Graft function assessment is crucial after kidney transplantation. Urine output (UOP) is the simplest, most feasible, and most cost-effective perioperative monitoring tool to assess graft function in kidney transplantation. No study, to our knowledge, has yet assessed this association in the setting of cadaveric adult kidney transplantation.

methodsWe conducted a retrospective single-centre cohort study to evaluate the impact of desmopressin on UOP in the immediate postoperative period after kidney transplantation at a tertiary care academic hospital in Baltimore, MD, USA. We included a total of 938 adults who received a cadaveric kidney transplant from January 2016 to December 2022 in the study after reviewing selection criteria. As the primary outcome, we compared immediate postoperative UOP (mL·kg

resultsThree hundred and fifty-nine (38%) patients received desmopressin intraoperatively. Using multivariable linear regression, desmopressin use was associated with 0.6 mL·kg

conclusionsIntraoperative desmopressin in adult cadaveric kidney transplant recipients was associated with reduced urine output in the postoperative period without any significant hemostatic benefit.

Indexed as

Deamino Arginine VasopressinHemostaticsIntraoperative CareKidney TransplantationAdultAgedBlood Loss, SurgicalCadaverCohort StudiesFemaleHumansMaleMiddle AgedPostoperative PeriodRetrospective StudiesDeamino Arginine VasopressinHemostaticsDesmopressinend-stage renal diseasegraftkidney transplantationurine output

Identifiers

PMID40119096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.