Evidence map›Paper›PMID 40119033›Full record

ArticleNature materials2025

Topological acoustofluidics.

Shuaiguo Zhao, Zhenhua Tian, Chen Shen, Shujie Yang, Jianping Xia, Teng Li, Zhemiao Xie, Peiran Zhang, Luke P Lee, Steven A Cummer and 1 more

Abstract read
In one paragraph

Article in Nature materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
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  5. Review
  6. Article
  7. Article
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  9. Article
  10. Article
  11. Article
  12. Article
  13. Metamaterials and Fluid Flows.Nature communications · 2026
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Microbioreactor design for eukaryotic cell-based biomedical applications.Frontiers in bioengineering and biotechnology · 2026
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shuaiguo Zhao *Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-0139-8466
Zhenhua Tian *Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-1903-5604
Chen Shen *Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0003-3535-8494
Shujie YangThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.
Jianping XiaThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0001-9902-0228
Teng LiDepartment of Mechanical Engineering, Virginia Tech, Blacksburg, VA, USA.ORCID http://orcid.org/0009-0005-4007-6012
Zhemiao XieThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.
Peiran ZhangThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.
Luke P LeeRenal Division and Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. lplee@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-1436-4054
Steven A CummerDepartment of Electrical and Computer Engineering, Duke University, Durham, NC, USA. cummer@duke.edu.ORCID http://orcid.org/0000-0002-0002-0613
Tony Jun HuangThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA. tony.huang@duke.edu.ORCID http://orcid.org/0000-0003-1205-3313

Funding

Development of a digital acoustofluidic system for automating liquid handling in biomedical researchR01GM141055 · NIGMS · DUKE UNIVERSITY · PI HUANG, TONY JUN · 2021 to 2024
$1.9M
Development of a multifunctional, acoustofluidic 3D bioprinter with single-cell resolutionR01GM144417 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Zhenhua Tian · 2022 to 2026
$1.8M
Enabling Efficient, Fast, Biocompatible Exosome Separation via AcoustofluidicsR01GM132603 · NIGMS · DUKE UNIVERSITY · PI HUANG, TONY JUN · 2019 to 2022
$1.7M
National Science Foundation (NSF) CBET-2243507National Science Foundation (NSF) CMMI-1951106National Science Foundation (NSF) CMMI-2104295National Science Foundation (NSF) CMMI2243771National Science Foundation (NSF) ECCS-2337069New Jersey Health Foundation (New Jersey Health Foundation, Inc.) PC 85-23NIGMS NIH HHS R01 GM132603NIGMS NIH HHS R01 GM141055NIGMS NIH HHS R01 GM144417U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM132603U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM144417
6 · The paper itself

Abstract

The complex interaction of spin, valley and lattice degrees of freedom allows natural materials to create exotic topological phenomena. The interplay between topological wave materials and hydrodynamics could offer promising opportunities for visualizing topological physics and manipulating bioparticle unconventionally. Here we present topological acoustofluidic chips to illustrate the complex interaction between elastic valley spin and nonlinear fluid dynamics. We created valley streaming vortices and chiral swirling patterns for backward-immune particle transport. Using tracer particles, we observed arrays of clockwise and anticlockwise valley vortices due to an increase in elastic spin density. Moreover, we discovered exotic topological pressure wells in fluids, creating nanoscale trapping fields for manipulating DNA molecules. We also found a 93.2% modulation in the bandwidth of edge states, dependent on the orientation of the substrate's crystallographic structure. Our study sets the stage for uncovering topological acoustofluidic phenomena and visualizing elastic valley spin, revealing the potential for topological-material applications in life sciences.

Identifiers

PMID40119033
PMCPMC12048345

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.