Evidence map›Paper›PMID 40119008›Full record

ArticleScientific reports2025

A multicenter retrospective study evaluating the effect of proton pump inhibitors on adjuvant tegafur-uracil/leucovorin efficacy for stage II-III colorectal cancer.

Masaya Takahashi, Katsuyuki Takahashi, Kanae Takahashi, Daichiro Fujiwara, Kaori Ito, Hirotake Yamase, Kaito Yamashiro, Hajime Asano, Naoki Yabuta, Tadafumi Hoshida and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Masaya TakahashiDivision of Social Pharmacy, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae Higashi-Osaka, Osaka, 577-8502, Japan.
Katsuyuki TakahashiDivision of Social Pharmacy, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae Higashi-Osaka, Osaka, 577-8502, Japan. k.taka@phar.kindai.ac.jp.ORCID http://orcid.org/0000-0001-9183-0760
Kanae TakahashiDepartment of Medical Statistics, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Daichiro FujiwaraDepartment of Pharmacy, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
Kaori ItoDepartment of Pharmacotherapeutics and Informatics, Fujita Health University School of Medicine, Aichi, Japan.
Hirotake YamaseDepartment of Pharmacy, Japanese Red Cross Osaka Hospital, Osaka, Japan.
Kaito YamashiroDepartment of Pharmacy, Kindai University Nara Hospital, Nara, Japan.
Hajime AsanoDivision of Pharmacy, Kindai University Hospital, Osaka, Japan.
Naoki YabutaDepartment of Pharmacy, Shiga University of Medical Science Hospital, Shiga, Japan.
Tadafumi HoshidaDepartment of Pharmacy, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
Takenao KosekiDepartment of Pharmacotherapeutics and Informatics, Fujita Health University School of Medicine, Aichi, Japan.
Masahito ShibanoDepartment of Pharmacy, Osaka Metropolitan University Hospital, Osaka, Japan.
Kanako TsukadaDepartment of Pharmacy, Japanese Red Cross Osaka Hospital, Osaka, Japan.
Yasuhiko TakataDepartment of Pharmacy, Kindai University Nara Hospital, Nara, Japan.
Yuika KomatsuDivision of Pharmacy, Kindai University Hospital, Osaka, Japan.
Satoshi NodaDepartment of Pharmacy, Shiga University of Medical Science Hospital, Shiga, Japan.
Kohei HashimotoDepartment of Medical Statistics, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Toru OtoriDivision of Social Pharmacy, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae Higashi-Osaka, Osaka, 577-8502, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We hypothesized that there is reduced efficacy of fluorinated pyrimidines, such as capecitabine, caused by low active folic acid levels induced by vitamin B

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsColorectal NeoplasmsLeucovorinProton Pump InhibitorsTegafurAdultAgedChemotherapy, AdjuvantFemaleHumansMaleMiddle AgedNeoplasm StagingRetrospective StudiesTreatment OutcomeUracilLeucovorinProton Pump InhibitorsTegafurUracilAdjuvant chemotherapyColorectal cancerProton pump inhibitorsReduced folic acidTegafur uracil plus leucovorin

Identifiers

PMID40119008
PMCPMC11928574

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.