ArticleScientific reports2025
Generalization and extinction of platform-mediated avoidance in male and female rats.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Top-down corticostriatal control of adaptive restraint during motivational conflict.Science advances · 2026Article
- High-fat diet exposure, internal state, and reward value influence decision making during motivational conflict.Neurobiology of stress · 2026Article
- Diazepam selectively biases approach during threat-reward conflict while sparing reactive avoidance.Psychopharmacology · 2026Article
- Rats use darting as a strategy to navigate between reward and safety during platform-mediated active avoidance under different social contexts.bioRxiv : the preprint server for biology · 2026Article
- Darting during platform-mediated avoidance in male and female rats is spatially organized between reward and safety locations.Frontiers in behavioral neuroscience · 2026Article
- Modifying the platform-mediated avoidance task: A new protocol to study active avoidance within a social context in rats.PloS one · 2025Article
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Authors and funding
3 authors.
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Abstract
Understanding anxiety-related disorders can be advanced by studying the fear learning mechanisms implicated in the transition from adaptive to maladaptive fear. Individuals with anxiety disorders often show impaired fear extinction, pervasive avoidance, and overgeneralization of fear. While these characteristics are usually studied in isolation, their interactions are less understood. We modified the platform-mediated avoidance task to chart avoidance, generalization, and extinction in male and female rats. Male rats acquired avoidance, showed a gradient of generalization, and reduced avoidance and fear under extinction. Female rats also learned avoidance, showed gradual generalization, and extinction of defensive behaviors. Sex differences emerged in extinction learning but were subtler than expected. We present an open-source automated system for processing DeepLabCut and SimBA output to score avoidance and freezing behavior. This task effectively probes avoidance, generalization, and extinction of fear in rats, and our automated scoring approach offers a effective method to quantify defensive behaviors.
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