ArticleNature communications2025
Enhancing prosthetic vision by upgrade of a subretinal photovoltaic implant in situ.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Bioelectronic interfaces for restoring vision pathways.Materials today. Bio · 2026Review
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- Revisiting retinal and macular degeneration in the genomics era.Nature reviews. Genetics · 2026Review
- Neural Vision Restoration in Ophthalmology.Annals of biomedical engineering · 2026Review
- Maximizing the fidelity of a photovoltaic subretinal prosthesis for human patients.Journal of neural engineering · 2026Article
- Design and Preclinical Validation of an Eyeglass-Coupled Perilimbal Antenna for Retinal Prostheses With a Biocompatible Graft Technique.Translational vision science & technology · 2026Article
- Restoration of Sight with Electronic Retinal Prostheses.Annual review of vision science · 2025Review
- Advances in Electrode Design and Physiological Considerations for Retinal Implants.Micromachines · 2025Review
- Enhancing prosthetic vision by upgrade of a subretinal photovoltaic implant in situ.Nature communications · 2025Article
- Article
- Review of brain-computer interface technology in ophthalmology: Current status, challenges and future directions.Advances in ophthalmology practice and researchReview
Corrections and comments
- Update of
Authors and funding
13 authors.
Funding
Abstract
In patients with atrophic age-related macular degeneration, subretinal photovoltaic implant (PRIMA) provided visual acuity up to 20/440, matching its 100 µm pixels size. Next-generation implants with smaller pixels should significantly improve the acuity. This study in rats evaluates removal of a subretinal implant, replacement with a newer device, and the resulting grating acuity in-vivo. Six weeks after the initial implantation with planar and 3-dimensional devices, the retina was re-detached, and the devices were successfully removed. Histology demonstrated a preserved inner nuclear layer. Re-implantation of new devices into the same location demonstrated retinal re-attachment to a new implant. New devices with 22 µm pixels increased the grating acuity from the 100 µm capability of PRIMA implants to 28 µm, reaching the limit of natural resolution in rats. Reimplanted devices exhibited the same stimulation threshold as for the first implantation of the same implants in a control group. This study demonstrates the feasibility of safely upgrading the subretinal photovoltaic implants to improve prosthetic visual acuity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.