Evidence map›Paper›PMID 40118870›Full record

ArticleScientific reports2025

Synthesis, in vitro, and in silico studies of 7-fluorochromone based thiosemicarbazones as α-glucosidase inhibitors.

Faiqa Noreen, Saeed Ullah, Suraj N Mali, Ajmal Khan, Javid Hussain, Abdulrahman Alshammari, Norah A Albekairi, Rahul D Jawarkar, Susmita Yadav, Ahmed Al-Harrasi and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. ADMET & DMPK · 2026
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Faiqa NoreenInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.
Saeed UllahNatural and Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, P.O. Box 33, PC, 616, Nizwa, Sultanate of Oman.
Suraj N MaliSchool of Pharmacy, D.Y. Patil University (Deemed to Be University), Sector 7, Nerul, Navi Mumbai, 400706, India.
Ajmal KhanNatural and Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, P.O. Box 33, PC, 616, Nizwa, Sultanate of Oman. ajmalkhan@unizwa.edu.om.
Javid HussainDepartment of Biological Sciences and Chemistry, University of Nizwa, Nizwa, Oman.
Abdulrahman AlshammariDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Post Box 2455, 11451, Riyadh, Saudi Arabia.
Norah A AlbekairiDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Post Box 2455, 11451, Riyadh, Saudi Arabia.
Rahul D JawarkarDepartment of Medicinal Chemistry and Drug Discovery, Dr. Rajendra Gode Institute of Pharmacy, University Mardi Road, Amravati, 444603, India.
Susmita YadavDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, 835215, India.
Ahmed Al-HarrasiNatural and Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, P.O. Box 33, PC, 616, Nizwa, Sultanate of Oman. aharrasi@unizwa.edu.om.
Zahid ShafiqInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan. zahidshafiq@bzu.edu.pk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased blood sugar is a typical manifestation of Type-2 Diabetes Mellitus (T2DM), a metabolic disorder that can be effectively managed with the help of α-glucosidase inhibitors. A range of new chromone based thiosemicarbazone derivatives (3a-t) was synthesized and assessed due to their ability to suppress α-glucosidase in this research. Having IC

Indexed as

alpha-GlucosidasesChromonesGlycoside Hydrolase InhibitorsThiosemicarbazonesDiabetes Mellitus, Type 2HumansMolecular Docking SimulationStructure-Activity Relationshipalpha-GlucosidasesChromonesGlycoside Hydrolase InhibitorsThiosemicarbazones7-fluorochromoneADMEMolecular dockingSARThiosemicarbazonesα-glucosidase inhibition

Identifiers

PMID40118870
PMCPMC11928550

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.