ArticleNature communications2025
Genetic properties underlying transcriptional variability across different perturbations.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed.
- Generative artificial intelligence in animal genomics for smart agriculture: Applications, challenges, and future prospects.Veterinary and animal science · 2026Review
- 400 nm femtosecond laser irradiation eradicates mature MRSA biofilms and inhibits their formation via quorum sensing dysregulation.Scientific reports · 2026Article
- Evolution of phenocopying in a dynamical model of developmental trajectories.PLoS computational biology · 2026Article
- Heterokairic Genes and the Eco-Evo-Devo of Timing.Evolution & development · 2026Review
- Bacterial gene regulatory neural network as a biocomputing library of mathematical solvers.NPJ systems biology and applications · 2026Article
- Simple biological controllers drive the evolution of soft modes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Bridging developmental and statistical approaches to variation and evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Repeatability of gene expression evolution in experimental environmental adaptation.Nature communications · 2026Article
- Congruence between noise and plasticity in protein expression.Scientific reports · 2025Article
- Soft Modes as a Predictive Framework for Low-Dimensional Biological Systems Across Scales.Annual review of biophysics · 2025Review
- Genetic properties underlying transcriptional variability across different perturbations.Nature communications · 2025Article
- Soft Modes as a Predictive Framework for Low Dimensional Biological Systems across Scales.ArXiv · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rate and direction of phenotypic evolution depend on the availability of phenotypic variants induced genetically or environmentally. It is widely accepted that organisms do not display uniform phenotypic variation, with certain variants arising more frequently than others in response to genetic or environmental perturbations. Previous studies have suggested that gene regulatory networks channel both environmental and genetic influences. However, how the gene regulatory networks influence phenotypic variation remains unclear. To address this, we characterize transcriptional variations in Escherichia coli under environmental and genetic perturbations. Based on the current understanding of transcriptional regulatory networks, we identify genetic properties that explain gene-to-gene differences in transcriptional variation. Our findings highlight the role of gene regulatory networks in shaping the shared phenotypic variability across different perturbations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.