ArticleTranslational psychiatry2025
Multi-omics insight into the molecular networks of mental disorder related genetic pathways in the pathogenesis of inflammatory bowel disease.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Neuronal Cell-Specific sc-eQTL and Integrative eQTL-pQTL Mendelian Randomization Prioritize CKAP2 as a Candidate Gene for Major Depressive Disorder.Journal of molecular neuroscience : MN · 2026Observational
- DNA Methylation-Regulated ZDHHC24 Exacerbates the Risk of Intracranial Aneurysms.Brain and behavior · 2026Article
- Honeysuckle-derived nanovesicles alleviate inflammatory bowel disease-associated neuropsychiatric disorders via the gut-brain axis.Theranostics · 2026Article
- From Genome-Wide SNPs to Neuroimmune Crosstalk: Mapping the Genetic Landscape of IBD and Its Brain Overlap.Biology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Mental disorders are associated with inflammatory bowel disease (IBD), but the genetic pathophysiology is not fully understood. We obtained data on mental disorder-related gene methylation, expression, protein levels, and summary statistics of IBD, and performed Summary data-based Mendelian randomization and colocalization analyses to explore the causal associations and shared causal genetic variants between multiple molecular traits and IBD. Integrating multi-omics data, we found QDPR, DBI and MAX are associated with ulcerative colitis (UC) risk, while HP is linked to IBD risk. Inverse associations between gene methylation (cg0880851 and cg26689483) and expression are observed in QDPR, consistent with their detrimental role in UC. Methylation of DBI (cg11066750) protects against UC by enhancing expression. Higher levels of DBI (OR = 0.79, 95%CI = 0.69-0.90) and MAX (OR = 0.74, 95%CI = 0.62-0.90) encoded proteins are inversely associated with UC risk, while higher QDPR (OR = 1.17, 95%CI = 1.07-1.28) and HP (OR = 1.09, 95%CI = 1.04-1.14) levels increase UC and IBD risk. Our findings advance the understanding of IBD's pathogenic mechanisms and gut-brain interaction.
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