Evidence map›Paper›PMID 40118610›Full record

ArticleJACC. Case reports2025

Unexplained Loss of Consciousness in a Patient With Klinefelter Syndrome and Brugada Syndrome.

Anna Kostopoulou, Vasileios Cheilas, Antonios Martinos, Polyxeni Gourzi, Malena Pantou, Artemis Nikolopoulou, Anna Siatouni, Michalis Efremidis

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna KostopoulouElectrophysiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
Vasileios CheilasElectrophysiology Department, Onassis Cardiac Surgery Center, Athens, Greece. Electronic address: cheilas_vasilis@hotmail.com.
Antonios MartinosElectrophysiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
Polyxeni GourziLaboratory of Molecular Immunopathology and Histocompatibility, Onassis Cardiac Surgery Center, Athens, Greece.
Malena PantouLaboratory of Molecular Immunopathology and Histocompatibility, Onassis Cardiac Surgery Center, Athens, Greece.
Artemis NikolopoulouElectrophysiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
Anna SiatouniLaboratory of Molecular Immunopathology and Histocompatibility, Onassis Cardiac Surgery Center, Athens, Greece.
Michalis EfremidisElectrophysiology Department, Onassis Cardiac Surgery Center, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Managing patients with both Klinefelter syndrome (KS) and Brugada syndrome (BrS) is challenging because of the rarity of this unique interaction. A man diagnosed with KS during fertility treatment experienced chronic muscle pain, severe depression, and cognitive difficulties, managed with testosterone therapy and antidepressants. Increased testosterone doses led to recurrent episodes of loss of consciousness, initially considered epileptic. Hormonal assessments, cardiac imaging, Holter monitoring, electrophysiological studies, and genetic testing led to BrS diagnosis. A positive ventricular tachycardia stimulation study led to the implantation of an implantable cardioverter-defibrillator. Following implantable cardioverter-defibrillator insertion, discontinuing testosterone, and changing medication, the patient has remained stable. The coexistence of KS and BrS is extremely rare. Understanding hormonal and genetic interactions in managing such complex cases is crucial.

Indexed as

arrhythmiasBrugada syndromecase reporthormonal imbalanceimplantable defibrillatorKlinefelter syndromeloss of consciousnesssudden cardiac deathsyncopetestosterone

Identifiers

PMID40118610
PMCPMC12011147

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Registered trials

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