ArticleJACC. Case reports2025
Diphtheritic Myocarditis in an Unvaccinated Child.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
backgroundDiphtheria, a preventable yet potentially fatal childhood disease, remains a significant threat to unimmunized children, despite its decreased prevalence due to widespread vaccination. CASE SUMMARY: A 6-year-old unvaccinated Spanish boy presented with diphtheritic myocarditis. His condition rapidly deteriorated, leading to cardiogenic shock and ventricular tachycardia, necessitating the use of venoarterial extracorporeal membrane oxygenation and the international procurement of diphtheritic antitoxin (DAT). DISCUSSION: Myocarditis stands as the primary cause of mortality in diphtheria. Early DAT administration is crucial, but its effectiveness diminishes once the diphtheria toxin binds to tissues, and global accessibility may be challenging due to limited production. In scenarios of refractory cardiogenic shock, the employment of mechanical circulatory support, specifically with left cavity drainage systems, can be vital. TAKE HOME MESSAGES: Timely vaccination is crucial in preventing diphtheria-related fatalities. Global access to essential treatments like DAT remains a significant challenge.
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