ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2026
Intrinsic Functional Connectivity of Right Dorsolateral Prefrontal Cortex and Hippocampus Subregions Relates to Emotional and Sensory-Perceptual Properties of Intrusive Trauma Memories.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Re-experiencing trauma: Occipital lobe resting-state functional connectivity in posttraumatic stress disorder.Psychiatry research. Neuroimaging · 2026Article
- From classic circuits to novel mechanisms: How lncRNA, neuroinflammation, and iPSC models address the translational crisis in PTSD research.Comprehensive psychoneuroendocrinology · 2026Review
- Microstructural Integrity of Hippocampal-Posterior Cortical White Matter Is Associated With Phenomenological Properties of Trauma-Related Intrusive Memories.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Scoping Review of Experience Sampling Methodology Investigations of Posttraumatic Stress Disorder Symptoms.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2026Article
- Implications for optimizing treatment timing: day of week variation in PTSD symptom clusters.Frontiers in psychiatry · 2025Article
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6 authors.
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Abstract
backgroundTrauma-related intrusive memories (TR-IMs) are core symptoms of posttraumatic stress disorder (PTSD). Prior research links reexperiencing symptoms with resting-state functional coupling between the right dorsolateral prefrontal cortex (dlPFC) and right hippocampus (HPC). However, prior work has not examined whether this negative coupling relates to TR-IMs or has differentiated between the anterior and posterior HPC (aHPC/pHPC). This study examined relationships of TR-IM frequency and properties with resting-state negative coupling between the right dlPFC and right aHPC/pHPC in symptomatic trauma-exposed individuals with TR-IMs.
methodsParticipants (N = 109; 88 female) completed 2 weeks of ecological momentary assessments capturing TR-IM frequency and properties (intrusiveness, emotional intensity, vividness, visual properties, and reliving). Using resting-state functional magnetic resonance imaging, participant-specific 4-mm spheres were placed at the right dlPFC voxel most anticorrelated with the right aHPC/pHPC. Quasi-Poisson and linear mixed-effect models assessed relationships of TR-IM frequency and properties with right dlPFC-right aHPC/pHPC anticorrelation.
resultsTR-IM emotional intensity was positively associated with right dlPFC-aHPC connectivity, while vividness and visual properties correlated with right dlPFC-pHPC connectivity. These associations remained significant after controlling for PTSD symptom severity and time since trauma. No significant associations emerged between TR-IM frequency, intrusiveness, or reliving and anticorrelation with either hippocampal subregion.
conclusionsThis study provides novel insights into the neural correlates of TR-IMs, highlighting the relevance of intrinsic negative coupling between the right dlPFC and aHPC/pHPC to their phenomenology. Further research on this circuit could advance understanding of component processes of trauma reexperiencing, a severe and treatment-refractory PTSD symptom.
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