Trial reportThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2025
Evaluating the mechanism of action behind controlled hypothermic preservation of donor hearts: A randomized pilot study.
Trial report in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Corrections and comments
- Erratum issued
Authors and funding
23 authors.
Funding
Abstract
backgroundControlled hypothermic preservation of donor hearts is associated with decreased post-transplant primary graft dysfunction compared to conventional cold storage. However, mechanisms underlying this benefit in human subjects are unclear.
methodsWe randomized 20 heart transplant recipients at a single institution to receive donor hearts preserved with either controlled hypothermic preservation or standard cold storage. Right ventricular biopsies were obtained at donor heart recovery, immediately before implantation, and 7 days after transplantation. Protein expression profiles at each time point were evaluated using mass spectrometry, Protein Interaction Network Extractor analysis, and Ingenuity Pathway Analysis.
resultsImmediately before implantation, controlled hypothermic preservation was associated with increased protein expression related to fatty acid metabolism, mitochondrial intermembrane space, and contractile fiber machinery. Pathway analysis indicated increased cell viability, autophagy, and upregulation of AMP-activated protein kinase pathway with controlled hypothermic preservation. By post-transplant day 7, the protein expression profiles of the 2 groups were similar. However, controlled hypothermic preservation was associated with increased expression in the peroxisome proliferator-activated receptor signaling pathway and fatty acid oxidation.
conclusionsControlled hypothermic preservation of donor hearts shows beneficial time-dependent variability in protein expression that may confer improved organ quality at the time of transplantation.
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