Evidence map›Paper›PMID 40118151›Full record

ArticleVirologica Sinica2025

The SARS-CoV-2 3CL protease inhibits pyroptosis through the cleavage of gasdermin D.

Yecheng Zhang, Xinlei Ji, Dan Huang, Gen Lu, Xinwen Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virologica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yecheng ZhangDepartment of Respiratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China.
Xinlei JiGuangzhou National Laboratory, Guangzhou 510005, China.
Dan HuangGuangzhou National Laboratory, Guangzhou 510005, China.
Gen LuDepartment of Respiratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China. Electronic address: lugen5663330@sina.com.
Xinwen ChenGuangzhou National Laboratory, Guangzhou 510005, China. Electronic address: chen_xinwen@gzlab.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of novel coronavirus disease 2019, can cause acute respiratory symptoms and even death globally. However, the immune escape mechanism and viral pathogenesis remain poorly understood. Here, we report that the SARS-CoV-2 3C-like (3CL) protease specifically cleaves gasdermin D (GSDMD) at Q29 and Q193, producing two N-terminal fragments, GSDMD

Indexed as

Coronavirus 3C ProteasesIntracellular Signaling Peptides and ProteinsNeoplasm ProteinsPhosphate-Binding ProteinsPyroptosisSARS-CoV-2COVID-19GasderminsHEK293 CellsHumansVirus Replication3C-like proteinase, SARS-CoV-2Coronavirus 3C ProteasesGasderminsGSDMD protein, humanIntracellular Signaling Peptides and ProteinsNeoplasm ProteinsPhosphate-Binding Proteins3C-like (3CL) proteaseGasdermin D (GSDMD)PyroptosisSARS-CoV-2

Identifiers

PMID40118151
PMCPMC12282442

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.