Evidence map›Paper›PMID 40118122›Full record

ArticleJournal of neuroscience methods2025

Magnetic resonance spectroscopy and the menstrual cycle: A multi-centre assessment of menstrual cycle effects on GABA & GSH.

Yulu Song, James J Prisciandaro, Dace Apšvalka, Mae Bernard, Adam Berrington, Miguel Castelo-Branco, Mark K Britton, Marta M Correia, Koen Cuypers, Aleksandra Domagalik and 33 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of neuroscience methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Yulu SongRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
James J PrisciandaroAddiction Sciences Division, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, USA.
Dace ApšvalkaMRC Cognition and Brain Sciences Unit, University of Cambridge, UK.
Mae BernardSchool of Psychology and Sports Sciences, Bangor University, Bangor, UK.
Adam BerringtonSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK.
Miguel Castelo-BrancoInstitute for Nuclear Sciences Applied to Health (ICNAS), Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Portugal.
Mark K BrittonCenter for Cognitive Aging and Memory and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Marta M CorreiaMRC Cognition and Brain Sciences Unit, University of Cambridge, UK.
Koen CuypersNeuroplasticity and Movement Control Research Group, Rehabilitation Research Institute (REVAL), Hasselt University, Diepenbeek, Belgium; Movement Control & Neuroplasticity Research Group, Department of Movement Sciences, Group Biomedical Sciences, KU Leuven, Heverlee, Belgium; Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium.
Aleksandra DomagalikCentre for Brain Research, Jagiellonian University, Krakow, Poland.
Ulrike DydakSchool of Health Sciences, Purdue University, West Lafayette, IN, USA; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Niall W DuncanGraduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan; Brain and Consciousness Research Centre, TMU Shuang-Ho Hospital, New Taipei City, Taiwan.
Gerard E DwyerDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway; NORMENT Centre of Excellence, Haukeland University Hospital, Bergen, Norway.
Tao GongDepartments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China; Departments of Radiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Jinan, Shandong, China.
Ian GreenhouseInstitute of Neuroscience, University of Oregon, Eugene, OR 97403, USA; Department of Human Physiology, University of Oregon, Eugene, OR 97403, USA.
Katarzyna HatDoctoral School in the Social Sciences, Jagiellonian University, Poland; Consciousness Lab, Institute of Psychology, Jagiellonian University, Kraków, Poland.
Melina HehlNeuroplasticity and Movement Control Research Group, Rehabilitation Research Institute (REVAL), Hasselt University, Diepenbeek, Belgium; Movement Control & Neuroplasticity Research Group, Department of Movement Sciences, Group Biomedical Sciences, KU Leuven, Heverlee, Belgium; Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium; Translational MRI, Department of Imaging & Pathology, KU Leuven, Leuven, Belgium.
Shiori HondaDepartment of Neuropsychiatry, Keio University, School of Medicine, Tokyo, Japan.
Chris HortonInstitute of Neuroscience, University of Oregon, Eugene, OR 97403, USA.
Steve C N HuiDeveloping Brain Institute, Children's National Hospital, Washington, DC, USA; Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Stephen R JacksonSchool of psychology, University of Nottingham, Nottingham, UK; Neurotherapeutics Ltd, The Ingenuity Centre, University of Nottingham Innovation Park, Triumph Road, Nottingham NG7 2TU, UK; Institute of Mental Health, School of Medicine, University of Nottingham, Nottingham, UK.
Daniella L JonesSchool of Psychology, University of Surrey, Guildford GU2 7XH, UK.
Maren S KlanGraduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan; Brain and Consciousness Research Centre, TMU Shuang-Ho Hospital, New Taipei City, Taiwan.
In Kyoon LyooEwha Brain Institute, Graduate School of Pharmaceutical Sciences, and Dept. of Brain and Cognitive Sciences, Ewha Womans University, Seoul, South Korea.
Marius O MadaMRC Cognition and Brain Sciences Unit, University of Cambridge, UK.
Bronte V McNamaraGraduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan; Brain and Consciousness Research Centre, TMU Shuang-Ho Hospital, New Taipei City, Taiwan.
Paul G MullinsSchool of Psychology and Sports Sciences, Bangor University, Bangor, UK.
Emlyn MuskaCenter for Cognitive Aging and Memory and McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, 1225 Center Drive, Gainesville, FL 32611, USA.
Shinichiro NakajimaConsciousness Lab, Institute of Psychology, Jagiellonian University, Kraków, Poland; Multimodal Imaging Group, Centre for Addiction and Mental Health, University of Toronto, Canada.
Hayami NishioInstitute of Neuroscience, University of Oregon, Eugene, OR 97403, USA.
Andreia C PereiraInstitute for Nuclear Sciences Applied to Health (ICNAS), Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Portugal.
Eric C PorgesCenter for Cognitive Aging and Memory and McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, 1225 Center Drive, Gainesville, FL 32611, USA.
Michelle RowsellMRC Cognition and Brain Sciences Unit, University of Cambridge, UK; School of Psychology and Sports Sciences, Bangor University, Bangor, UK.
Rubi RuoppInstitute of Neuroscience, University of Oregon, Eugene, OR 97403, USA.
Destin D ShortellCenter for Cognitive Aging and Memory and McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, 1225 Center Drive, Gainesville, FL 32611, USA.
Caitlin M SmithSchool of psychology, University of Nottingham, Nottingham, UK.
Stephan SwinnenMovement Control & Neuroplasticity Research Group, Department of Movement Sciences, Group Biomedical Sciences, KU Leuven, Heverlee, Belgium; Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium.
Antonia ŠušnjarWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 4796, USA.
Lin-Yuan TsengGraduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan; Brain and Consciousness Research Centre, TMU Shuang-Ho Hospital, New Taipei City, Taiwan.
Ines R ViolanteSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Sujung YoonEwha Brain Institute, Graduate School of Pharmaceutical Sciences, and Dept. of Brain and Cognitive Sciences, Ewha Womans University, Seoul, South Korea.
Richard A E EddenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Katherine DykeSchool of psychology, University of Nottingham, Nottingham, UK. Electronic address: Katherine.Dyke@nottingham.ac.uk.

Funding

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu · 2021 to 2026
$9.9M
Universal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4M
Simultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8M
Gabapentin for Restoring GABA/glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Clinical MRI StudyR01DA054275 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PRISCIANDARO, JAMES JOSEPH · 2021 to 2025
$3.1M
Mentorship and Research in Bipolar and Substance Use DisordersK24AA030788 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI James Joseph Prisciandaro · 2023 to 2026
$860k
NIAAA NIH HHS K24 AA030788NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963NIDA NIH HHS R01 DA054275
6 · The paper itself

Abstract

backgroundGamma-aminobutyric acid (GABA) and glutathione (GSH) play a significant role in the functioning of a healthy brain and can both be quantified using magnetic resonance spectroscopy (MRS). Several small-scale studies have suggested MRS measured GABA may fluctuate with the menstrual cycle, but the effects on GSH are unknown. Utilising recent developments in MRS acquisition, this multi-lab study explores this issue across 4 distinctive brain regions. NEW

methodsData were analysed from 12 independent sites from which a total of 30 women were scanned during three phases of their menstrual cycle corresponding to early follicular, ovulation and mid luteal phases. HERMES and HERCULES sequences were used to measure GABA and GSH in voxels located in the left motor cortex, left posterior insular, medial parietal and medial frontal. Linear mixed models were used to assess the variability contributed by site, participant and menstrual cycle phase.

resultsSimilar variance was attributed to site and menstrual cycle phase for both GABA and GSH data. No systematic changes in GABA or GSH were revealed for any voxel as a consequence of menstrual cycle phase. COMPARISON WITH EXISTING

methodsDespite our larger sample size and inclusion of more brain regions we fail to replicate previous findings of GABA change as a consequence of menstrual cycle phase. We also show for the first time that MRS measures of GSH so not significantly alter with cycle.

conclusionsOur findings suggest that the menstrual cycle has minimal impact on MRS measures of GABA and GSH. The presence of a menstrual cycle should not be used as justification for exclusion of women in MRS studies.

Indexed as

Braingamma-Aminobutyric AcidGlutathioneMenstrual CycleAdultFemaleHumansMagnetic Resonance SpectroscopyYoung Adultgamma-Aminobutyric AcidGlutathioneGamma-aminobutyric acid (GABA)Glutathione (GSH)Hadamard Encoding and Reconstruction of MEGA-EditedMagnetic resonance, spectroscopy (MRS)Menstrual cycleOestrogenSpectroscopy (HERMES)

Identifiers

PMID40118122
PMCPMC13339251

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