ArticleJournal of the American Chemical Society2025
Late-Stage Photoredox-Catalyzed Aryl C-H Bond Diazomethylation with Atomic Carbon Reagents.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Deoxygenative Single-Carbon Atom Transfer: Accessing Strained Carbocycles From Alkenes and Aldehydes With Designer Dual-Functional Reagent.Angewandte Chemie (International ed. in English) · 2026Article
- Photoinduced Selective Construction of Densely Functionalized Spirocyclic Ethers With Carbyne Equivalents.Angewandte Chemie (International ed. in English) · 2026Article
- Single-carbon-atom transfer toChemical science · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein, we present a novel class of diazo compounds as atomic carbon reagents substituted with two orthogonal redox-active leaving groups that were exploited in the late-stage construction of chiral centers with aryl C-H bonds from aromatic feedstocks and drug molecules. Key to the strategy was the use of photoredox catalysis to enable an initial C-H diazomethylation reaction able to generate diazomethyl-substituted redox-active esters. Subsequent construction of chiral centers with readily available starting materials proceeded using a broad range of well-known diazo and redox-active ester functionalizations. Moreover, the applicability of our novel atomic carbon reagent was tested in the automated parallel synthesis of a library of Fenofibrate derivatives.
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Registered trials
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