Evidence map›Paper›PMID 40117716›Full record

ReviewCurrent opinion in chemical biology2025

Redirecting the host immune response to bacterial infection with antibody-recruiting molecules (ARMs).

Priscilla Dzigba, Megan A Seth, Mallary C Greenlee-Wacker, Benjamin M Swarts

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Priscilla DzigbaDepartment of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI, USA; Biochemistry, Cell, and Molecular Biology Graduate Programs, Central Michigan University, Mount Pleasant, MI, 48859, USA.
Megan A SethBiological Sciences Department, California Polytechnic State University, San Luis Obispo, CA, 93407, USA.
Mallary C Greenlee-WackerBiological Sciences Department, California Polytechnic State University, San Luis Obispo, CA, 93407, USA. Electronic address: mcgreenl@calpoly.edu.
Benjamin M SwartsDepartment of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI, USA; Biochemistry, Cell, and Molecular Biology Graduate Programs, Central Michigan University, Mount Pleasant, MI, 48859, USA. Electronic address: ben.swarts@cmich.edu.

Funding

Chemoenzymatic synthesis of trehalose analogues as tools for investigating mycobacteriaR15AI117670 · NIAID · CENTRAL MICHIGAN UNIVERSITY · PI SWARTS, BENJAMIN MICHAEL, WOODRUFF, PETER J · 2015 to 2024
$1.3M
NIAID NIH HHS R15 AI117670
6 · The paper itself

Abstract

The increasing prevalence of antibiotic resistance, the stagnation of antibiotic development, and the adaptive capacity of bacteria to subvert the host immune response combine to pose significant global health concerns. Consequently, there is an urgent need to develop alternative therapeutic approaches to combat bacterial infections. Antibody-recruiting molecules (ARMs), which are bispecific small molecules that recruit endogenous antibodies to pathogenic cells or viruses, offer a promising avenue to harness the host immune system to target various diseases. In this review, we cover ARM strategies that have been developed for bacterial pathogens, including Gram-positive bacteria, Gram-negative bacteria, and mycobacteria, and we discuss the prospects and challenges of utilizing ARMs as alternatives to traditional antibiotic therapies.

Indexed as

Anti-Bacterial AgentsBacterial InfectionsAnimalsBacteriaHumansAnti-Bacterial AgentsAntibodyAntibody-recruiting moleculeAntigenBacterial infectionCell surface engineeringGram-negative bacteriaGram-positive bacteriaHaptenImmunotherapyMycobacteriaOpsonization

Identifiers

PMID40117716
PMCPMC12306629

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.