Evidence map›Paper›PMID 40117669›Full record

ArticleJournal of neurosurgery. Pediatrics2025

Racial disparities in hydrocephalus mortality and shunt revision: a study from the Hydrocephalus Clinical Research Network.

Brandon G Rocque, Hailey Jensen, Ron W Reeder, Curtis J Rozzelle, Abhaya V Kulkarni, Ian F Pollack, Michael M McDowell, Robert P Naftel, Eric M Jackson, William E Whitehead and 15 more

Abstract read
In one paragraph

Article in Journal of neurosurgery. Pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Brandon G Rocque1Department of Neurosurgery, Children's of Alabama, The University of Alabama at Birmingham, Alabama.
Hailey JensenDepartments of2Pediatrics and.
Ron W ReederDepartments of2Pediatrics and.
Curtis J Rozzelle1Department of Neurosurgery, Children's of Alabama, The University of Alabama at Birmingham, Alabama.
Abhaya V Kulkarni3Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada.
Ian F Pollack4Department of Neurosurgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pennsylvania.
Michael M McDowell4Department of Neurosurgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pennsylvania.
Robert P Naftel5Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Eric M Jackson7Department of Neurosurgery, The Johns Hopkins Hospital, Johns Hopkins University, Baltimore, Maryland.
William E Whitehead8Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.
Jonathan A Pindrik9Department of Neurosurgery, The Ohio State University College of Medicine, Columbus, Ohio.
Albert M Isaacs9Department of Neurosurgery, The Ohio State University College of Medicine, Columbus, Ohio.
Jennifer M Strahle10Department of Neurosurgery, Washington University School of Medicine in St. Louis, Missouri.
Patrick J McDonald11Division of Neurosurgery, British Columbia Children's Hospital, The University of British Columbia, Vancouver, British Columbia, Canada.
Mandeep S Tamber11Division of Neurosurgery, British Columbia Children's Hospital, The University of British Columbia, Vancouver, British Columbia, Canada.
Todd C Hankinson12Department of Neurosurgery, Children's Hospital Colorado, Aurora, Colorado.
Samuel R Browd13Department of Neurosurgery, Seattle Children's Hospital, University of Washington, Seattle, Washington.
Jason S Hauptman14Department of Neurosurgery, Phoenix Children's Hospital, Phoenix, Arizona.
Mark D Krieger15Department of Neurosurgery, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California.
Jason Chu16Department of Neurosurgery, Riley Children's Hospital, Indiana University School of Medicine, Indianapolis, Indiana.
Jay Riva-Cambrin17Division of Neurosurgery, Alberta Children's Hospital, University of Calgary, Alberta, Canada; and.
David D Limbrick18Department of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia.
Richard HolubkovDepartments of2Pediatrics and.
John R W Kestle19Neurosurgery, University of Utah, Salt Lake City, Utah.
John C Wellons5Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee.

Funding

Endoscopic versus Shunt Treatment of Hydrocephalus in InfantsU01NS107486 · NINDS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Richard Holubkov, John Kestle · 2019 to 2026
$9.6M
Hydrocephalus Clinical Research Network: a consortium for pediatric hydrocephalusRC1NS068943 · NINDS · UNIVERSITY OF UTAH · PI KESTLE, JOHN · 2009 to 2010
$995k
NINDS NIH HHS RC1 NS068943NINDS NIH HHS U01 NS107486
6 · The paper itself

Abstract

objectiveSeveral studies of administrative data have noted higher mortality rates for Black/African American children with shunted hydrocephalus. A longitudinal study of children with hydrocephalus secondary to myelomeningocele showed lower lifetime rates of shunt revision in minority children compared to White children, indicating a possible disparity in hydrocephalus treatment. The goal of this study is to identify racial and ethnic disparities in mortality or in shunt revision rates by using the Hydrocephalus Clinical Research Network (HCRN) hydrocephalus registry sample.

methodsThe HCRN registry was queried for patients with shunted hydrocephalus for whom data on all lifetime hydrocephalus procedures were available. Patients with a primary shunt placement prior to 2023 were included, with follow-up extending through March 19, 2024. A Cox proportional hazards model was created to determine the effect of race and ethnicity on mortality while controlling for age at initial shunt placement, sex, hydrocephalus etiology, gestational age at birth, and presence of complex chronic conditions. Similarly, a proportional means model was used to evaluate association with lifetime number of shunt revision surgeries. The authors' hypothesis was that when controlling for other variables, minority children would have higher mortality and fewer shunt revision surgeries than White children.

resultsA total of 5656 children were included in the analysis of mortality. There were 579 deaths. Race and ethnicity were independently associated with mortality, with Black (HR 1.32, 95% CI 1.05-1.65), other non-White (HR 1.39, 95% CI 1.03-1.86), and Hispanic (HR 1.50, 95% CI 1.22-1.84) children having a higher mortality rate than White children. In the analysis of 4081 children with shunts, Hispanic ethnicity was also independently associated with fewer total shunt revisions (HR 0.84, 95% CI 0.72-0.98).

conclusionsIn children with hydrocephalus, when controlling for other factors, there is a higher mortality rate among Hispanic, Black, and other non-White children, and fewer shunt revisions among Hispanic children. These findings highlight important potential disparities in hydrocephalus treatment.

Indexed as

Cerebrospinal Fluid ShuntsHealthcare DisparitiesHydrocephalusReoperationBlack or African AmericanChildChild, PreschoolFemaleHispanic or LatinoHumansInfantInfant, NewbornMaleMeningomyeloceleRegistriesWhitehealthcare disparitieshydrocephalusmortalityventriculoperitoneal shunt

Identifiers

PMID40117669
PMCPMC12159845

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.