ArticleDermatology practical & conceptual2025
Causal Relationship Between Psoriasis and Bullous Pemphigoid: A Mendelian Randomization Analysis.
Article in Dermatology practical & conceptual, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Bullous Pemphigoid Overlapping Psoriasis Vulgaris: A Rare Case Report and Literature Review.Clinics and practice · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPsoriasis and bullous pemphigoid (BP) are the two major types of immune-mediated inflammatory skin diseases. Studies have reported the association between psoriasis and BP; however, no studies have reported whether a causal relationship exists between these two skin diseases.
objectivesIn order to explore the causal relationship between psoriasis and BP, we performed a bidirectional two-sample Mendelian randomization (MR) study.
methodsGenome-wide association study (GWAS) data related to psoriasis and BP were collected. The inverse-variance weighted (IVW) method was primarily applied for our MR analysis; MR-Egger, weighted median, simple mode, and weighted mode methods were also used. Heterogeneity, horizontal pleiotropy, and potential outliers were assessed for the MR analysis results.
resultsGWAS data for psoriasis (three cohorts) and BP (one cohort) from publicly available trials were selected. Our MR results showed that psoriasis was causally associated with BP, that psoriasis could increase the risk of BP, and that reversed MR showed BP has no causal effect on psoriasis. No heterogeneity or pleiotropy was detected.
conclusionThese findings provided new evidence of the causal relationship between psoriasis and BP. Our MR suggested that psoriasis is potentially causal to BP, which helps us to improve the treatment strategy for patients with psoriasis. The mechanism remains open for further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.