Evidence map›Paper›PMID 40117561›Full record

ArticleAging2025

Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP).

Sudipta Bar, Tyler A U Hilsabeck, Blaine Pattavina, José Alberto López-Domínguez, Nathan Basisty, Joanna Bons, Mark Watson, Birgit Schilling, Judith Campisi, Pankaj Kapahi and 1 more

Abstract read
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. ADAM19: biological characteristics and implications in disease pathology and clinical applications.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  2. International journal of molecular sciences · 2026
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sudipta BarBuck Institute for Research on Aging, Novato, CA 94945, USA.
Tyler A U HilsabeckBuck Institute for Research on Aging, Novato, CA 94945, USA.
Blaine PattavinaBuck Institute for Research on Aging, Novato, CA 94945, USA.
José Alberto López-DomínguezBuck Institute for Research on Aging, Novato, CA 94945, USA.
Nathan BasistyBuck Institute for Research on Aging, Novato, CA 94945, USA.
Joanna BonsBuck Institute for Research on Aging, Novato, CA 94945, USA.
Mark WatsonBuck Institute for Research on Aging, Novato, CA 94945, USA.
Birgit SchillingBuck Institute for Research on Aging, Novato, CA 94945, USA.
Judith CampisiBuck Institute for Research on Aging, Novato, CA 94945, USA.
Pankaj KapahiBuck Institute for Research on Aging, Novato, CA 94945, USA.
Amit SharmaBuck Institute for Research on Aging, Novato, CA 94945, USA.

Funding

THE IMPACT OF CELLULAR DEFENSE ON THE ROLE OF Ku80 IN GENOME MAINTENANCE AND LONGP01AG017242 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI VIJG, JAN · 1999 to 2023
$46.1M
Quantitative Proteomics to Develop Robust Senescence-Related Biomarkers for AgingU01AG060906 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI SCHILLING, BIRGIT · 2018 to 2022
$4.0M
Molecular Mechanisms of Lifespan Extension by Dietary Restriction in DrosophilaR01AG038688 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI KAPAHI, PANKAJ · 2011 to 2015
$2.3M
Role of Circadian Clocks in Aging using DrosophilaR01AG045835 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI KAPAHI, PANKAJ · 2013 to 2017
$2.1M
The role of natural genetic variants in nutrient-dependent changes in healthspan using D. melanogasterR21AG054121 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI BREM, RACHEL BETH, KAPAHI, PANKAJ · 2017 to 2018
$825k
TripleTOF 5600 High Resolution Mass SpectrometerS10OD016281 · OD · BUCK INSTITUTE FOR RESEARCH ON AGING · PI GIBSON, BRADFORD WAYNE · 2013 to 2013
$597k
NIA NIH HHS P01 AG017242NIA NIH HHS R01 AG038688NIA NIH HHS R01 AG045835NIA NIH HHS R21 AG054121NIA NIH HHS U01 AG060906NIH HHS S10 OD016281
6 · The paper itself

Abstract

Accumulation of DNA damage can accelerate aging through cellular senescence. Previously, we established a

Indexed as

ADAM ProteinsCellular SenescenceDrosophila ProteinsSenescence-Associated Secretory PhenotypeAgingAnimalsDNA DamageGenome-Wide Association StudyHumansMicePermeabilityADAM19 protein, humanADAM ProteinsDrosophila ProteinsagingdrosophilaSASPsenescence

Identifiers

PMID40117561
PMCPMC11984429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.