Evidence map›Paper›PMID 40117458›Full record

ArticleACS nano2025

Protein Carrier Adeno-Associated Virus.

Mareike Daniela Hoffmann, Ryan James Sorensen, Ajay Extross, Yungui He, Daniel Schmidt

Abstract read
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mareike Daniela HoffmannDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0001-8377-1385
Ryan James SorensenDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Ajay ExtrossDepartment of Molecular, Cellular, Developmental Biology, and Genetics, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Yungui HeDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Daniel SchmidtDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0001-7609-4873

Funding

Viral Innovation CoreP30DA048742 · NIDA · UNIVERSITY OF MINNESOTA · PI Mark John Thomas · 2020 to 2026
$19.0M
Viral vector technology for cell type specific gene deliveryR01GM141152 · NIGMS · UNIVERSITY OF MINNESOTA · PI SCHMIDT, DANIEL · 2022 to 2025
$1.5M
Proof of concept studies for in vivo produced CAR-T cells that target B cell follicles as a treatment for HIVR41AI184054 · NIAID · MARPAM PHARMA, LLC · PI ATHANASIOU, MARIA CONSTANCE, SCHMIDT, DANIEL · 2024 to 2024
$302k
NIAID NIH HHS R41 AI184054NIDA NIH HHS P30 DA048742NIGMS NIH HHS R01 GM141152
6 · The paper itself

Abstract

Adeno-associated virus (AAV) has emerged as a leading platform for gene therapy, enabling the delivery of therapeutic DNA to target cells. However, the potential of AAV to deliver protein payloads has been unexplored. In this study, we engineered a protein carrier AAV (pcAAV) to package and deliver proteins by inserting binding domains on the interior capsid surface. These binding domains mediate the packaging of specific target proteins through interaction with cognate peptides or protein tags during the capsid assembly process. We demonstrate the packaging of multiple proteins, including green fluorescent protein,

Indexed as

DependovirusGenetic VectorsCRISPR-Associated Protein 9Green Fluorescent ProteinsHEK293 CellsHumansIntegrasesCre recombinaseCRISPR-Associated Protein 9Green Fluorescent ProteinsIntegrasesadeno-associated viruscapsid engineeringnanoparticlesprotein deliverysynthetic virology

Identifiers

PMID40117458
PMCPMC11966780

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.