Evidence map›Paper›PMID 40117361›Full record

ArticleScience advances2025

CD38-mediated metabolic reprogramming promotes the stability and suppressive function of regulatory T cells in tumor.

Ishita Sarkar, Debashree Basak, Puspendu Ghosh, Anupam Gautam, Arpita Bhoumik, Praveen Singh, Anwesha Kar, Shaun Mahanti, Snehanshu Chowdhury, Lagnajita Chakraborty and 7 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Cytotoxic CD4Nature aging · 2026
    Article
  3. Article
  4. Peripheral Immune Remodeling After Spinal Cord Injury: Marked by Expansion of CD38Neurology(R) neuroimmunology & neuroinflammation · 2026
    Observational
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ishita SarkarDivision of Cancer Biology and Inflammatory Disorder, IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India.ORCID 0009-0001-4191-5181
Debashree BasakDivision of Cancer Biology and Inflammatory Disorder, IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India.
Puspendu GhoshDivision of Cancer Biology and Inflammatory Disorder, IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India.ORCID 0000-0003-0920-2306
Anupam GautamInstitute for Bioinformatics and Medical Informatics, University of Tübingen, Sand 14, 72076 Tübingen, Germany.ORCID 0000-0002-6460-6525
Arpita BhoumikDivision of Cancer Biology and Inflammatory Disorder, IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India.
Praveen SinghAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Anwesha KarDivision of Cancer Biology and Inflammatory Disorder, IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India.
Shaun MahantiDivision of Cancer Biology and Inflammatory Disorder, IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India.ORCID 0009-0000-9427-6945
Snehanshu ChowdhuryDivision of Cancer Biology and Inflammatory Disorder, IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India.ORCID 0000-0002-7114-4656
Lagnajita ChakrabortyAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Soumya MondalDepartment of Urology, IPGME&R and SSKM Hospital, Kolkata, India.ORCID 0000-0002-5023-7773
Ramanuj MukherjeeR.G. Kar Medical College and Hospitals, Kolkata, India.ORCID 0000-0002-5098-973X
Shikhar MehrotraMedical University of South Carolina.ORCID 0000-0002-5411-9504
Saikat MajumderAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Shantanu SenguptaAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.ORCID 0000-0001-8461-0735
Sandip PaulCenter for Health Science and Technology, JIS Institute of Advanced Studies and Research, JIS University, Kolkata, India.ORCID 0000-0001-7406-3598
Shilpak ChatterjeeDivision of Cancer Biology and Inflammatory Disorder, IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India.ORCID 0000-0002-8428-6434

Funding

DBT-Wellcome Trust India Alliance IA/I/19/1/504277Wellcome Trust
6 · The paper itself

Abstract

In the tumor microenvironment (TME), regulatory T cells (T

Indexed as

ADP-ribosyl Cyclase 1Membrane GlycoproteinsNeoplasmsT-Lymphocytes, RegulatoryAnimalsCell Line, TumorCitric Acid CycleDNA MethylationForkhead Transcription FactorsHumansMetabolic ReprogrammingMiceNADTumor MicroenvironmentADP-ribosyl Cyclase 1Forkhead Transcription FactorsMembrane GlycoproteinsNAD

Identifiers

PMID40117361
PMCPMC11927613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.