Evidence map›Paper›PMID 40117359›Full record

ArticleScience advances2025

Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD

Keisuke Yaku, Sailesh Palikhe, Tooba Iqbal, Faisal Hayat, Yoshiyuki Watanabe, Shiho Fujisaka, Hironori Izumi, Tomoyuki Yoshida, Mariam Karim, Hitoshi Uchida and 5 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Gut · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Nicotinamide mononucleotide alleviates the streptozotocin-mediated ferroptosis of islet β-cells via the Nrf2/GPX4 pathway.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Article
  16. The microbiome at the centre of NADNature metabolism · 2026
    Article
  17. Article
  18. Review
  19. Article
  20. NADNature metabolism · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Keisuke YakuDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.ORCID 0000-0002-2420-4265
Sailesh PalikheDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.ORCID 0000-0003-2511-9043
Tooba IqbalDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.ORCID 0009-0002-8207-3678
Faisal HayatMitchell Cancer Institute, Department of Pharmacology, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36693, USA.ORCID 0000-0001-5493-0199
Yoshiyuki WatanabeFirst Department of Internal Medicine, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.ORCID 0009-0000-6921-8188
Shiho FujisakaFirst Department of Internal Medicine, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.ORCID 0000-0003-0554-9003
Hironori IzumiDepartment of Molecular Neuroscience, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.ORCID 0009-0007-7580-1987
Tomoyuki YoshidaDepartment of Molecular Neuroscience, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.ORCID 0000-0002-8476-3798
Mariam KarimDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.ORCID 0009-0005-1770-6477
Hitoshi UchidaDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.ORCID 0000-0001-5372-5134
Allah NawazDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.ORCID 0000-0002-1979-9575
Kazuyuki TobeFirst Department of Internal Medicine, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.ORCID 0000-0003-0015-0255
Hisashi MoriDepartment of Molecular Neuroscience, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.ORCID 0000-0001-9743-2456
Marie E MigaudMitchell Cancer Institute, Department of Pharmacology, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36693, USA.ORCID 0000-0002-9626-2405
Takashi NakagawaDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.ORCID 0000-0001-5539-7605

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Decreased nicotinamide adenine dinucleotide (oxidized form) (NAD

Indexed as

NADNiacinamideNicotinamide MononucleotidePyridinium CompoundsAdministration, OralAnimalsGastrointestinal MicrobiomeLiverMaleMetabolomicsMiceMice, Inbred C57BLNADNiacinamidenicotinamide-beta-ribosideNicotinamide MononucleotidePyridinium Compounds

Identifiers

PMID40117359
PMCPMC11927621

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.