Evidence map›Paper›PMID 40117345›Full record

ArticleScience immunology2025

GM-CSF-mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to

Kathleen A M Mills, Frederike Westermann, Vanessa Espinosa, Eric Rosiek, Jigar V Desai, Mariano A Aufiero, Yahui Guo, Fitty L Liu, Kennedy A Mitchell, Selma Tuzlak and 5 more

Abstract read
In one paragraph

Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. The C-type lectin receptor Dcir (Frontiers in immunology · 2025
    Article
  15. Epithelial responses to fungal pathogens.Current opinion in microbiology · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Kathleen A M MillsImmunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.ORCID 0000-0002-6476-1023
Frederike WestermannInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-3253-2322
Vanessa EspinosaCenter for Immunity and Inflammation, New Jersey Medical School, Rutgers-State University of New Jersey, Newark, NJ, USA.ORCID 0000-0003-4808-3557
Eric RosiekMolecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-6355-1457
Jigar V DesaiFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8823-0796
Mariano A AufieroLouis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-2462-438X
Yahui GuoInfectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-1587-4619
Fitty L LiuImmunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.ORCID 0000-0001-5144-2827
Kennedy A MitchellInfectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0009-0005-8043-8372
Selma TuzlakInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-2406-1479
Donatella De FeoInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-0121-5364
Michail S LionakisFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-4994-9500
Amariliz RiveraCenter for Immunity and Inflammation, New Jersey Medical School, Rutgers-State University of New Jersey, Newark, NJ, USA.ORCID 0000-0002-2173-5597
Burkhard BecherInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-1541-7867
Tobias M HohlImmunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.ORCID 0000-0002-9097-5412

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
INITIATION OF THE IMMUNE RESPONSE TO ASPERGILLUS FUMIGATUSR37AI093808 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI TOBIAS M HOHL · 2021 to 2026
$4.2M
Antifungal Immunity and the Mechanism of Fungal Programmed Cell DeathR01AI139632 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI CRAMER, ROBERT ANDREW, HOHL, TOBIAS M · 2019 to 2023
$3.3M
Trained immunity and the regulation of anti-fungal defenseR01AI169769 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Amariliz Rivera, Chaoyang Xue · 2022 to 2026
$3.1M
The role of pathogen-experienced macrophage subsets in mediating lung immunity and heterologous protectionR01AI169770 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI William Clark Gause, Amariliz Rivera · 2023 to 2026
$3.1M
Immunology and Microbial Pathogenesis Research Training ProgramT32AI134632 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI EHRT, SABINE, LI, MING · 2019 to 2023
$747k
Elucidating the roles of systemic and mucosal complement in protection against invasive fungal infections impacting hematopoietic cell transplantR00AI141622 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI DESAI, JIGARKUMAR V · 2022 to 2023
$498k
IL-1 signaling in defense against Aspergillus fumigatus infectionF31AI167511 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI MILLS, KATHLEEN · 2022 to 2024
$143k
Deciphering the Role of Lysosomal Biogenesis in Anti-Aspergillus Immune ResponsesF31AI161996 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI AUFIERO, MARIANO ALEJANDRO · 2021 to 2023
$140k
NCI NIH HHS P30 CA008748NIAID NIH HHS F31 AI161996NIAID NIH HHS F31 AI167511NIAID NIH HHS K99 AI141622NIAID NIH HHS R00 AI141622NIAID NIH HHS R01 AI139632NIAID NIH HHS R01 AI169769NIAID NIH HHS R01 AI169770NIAID NIH HHS R37 AI093808NIAID NIH HHS T32 AI134632
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AspergillosisAspergillus fumigatusEpithelial CellsGranulocyte-Macrophage Colony-Stimulating FactorLungPulmonary AspergillosisAnimalsHumansMiceMice, Inbred C57BLMice, KnockoutNeutrophilsGranulocyte-Macrophage Colony-Stimulating Factor

Identifiers

PMID40117345
PMCPMC12122100

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.