Evidence map›Paper›PMID 40117308›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

ETV5 reduces androgen receptor expression and induces neural stem-like properties during neuroendocrine prostate cancer development.

Jongeun Lee, Jiho Park, Yunjung Hur, Dahun Um, Hyung-Seok Choi, Joonyoung Park, Yewon Kim, Jeon-Soo Lee, Kyuha Choi, Eunjeong Kim and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jongeun LeeDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.ORCID 0000-0003-4668-2329
Jiho ParkDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.
Yunjung HurDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.ORCID 0009-0002-5498-8678
Dahun UmDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.
Hyung-Seok ChoiDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.ORCID 0009-0003-0568-0762
Joonyoung ParkDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.ORCID 0009-0007-5334-3372
Yewon KimDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.ORCID 0009-0004-5575-1765
Jeon-Soo LeeDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.
Kyuha ChoiDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.ORCID 0000-0002-4072-3807
Eunjeong KimDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Young Bin ParkCalici Co., Ltd., Korea, Daejeon 34134, Republic of Korea.ORCID 0009-0006-7495-6322
Jae-Mun ChoiCalici Co., Ltd., Korea, Daejeon 34134, Republic of Korea.
Tae-Kyung KimDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.
Yoontae LeeDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.ORCID 0000-0002-6810-3087

Funding

Ministry of Education (교육부) 2021R1A6C101A390National Research Foundation of Korea (NRF) 2021R1A6A1A10042944National Research Foundation of Korea (NRF) 2022M3E5F2018020National Research Foundation of Korea (NRF) 2022R1A6A3A13070548National Research Foundation of Korea (NRF) NRF-2018H1A2A1059794National Research Foundation of Korea (NRF) RS-2023-00260454National Research Foundation of Korea (NRF) RS-2023-00276340National Research Foundation of Korea (NRF) RS-2024-00336114
6 · The paper itself

Abstract

Neuroendocrine prostate cancer (NEPC), an aggressive subtype induced by hormone therapy, lacks effective treatments. This study explored the role of E26 transformation-specific variant 5 (ETV5) in NEPC development. Analysis of multiple prostate cancer datasets revealed that NEPC is characterized by significantly elevated

Indexed as

Carcinoma, NeuroendocrineDNA-Binding ProteinsNeural Stem CellsNeuroendocrine TumorsProstatic NeoplasmsReceptors, AndrogenTranscription FactorsAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMaleMiceAR protein, humanDNA-Binding ProteinsETV5 protein, humanReceptors, AndrogenTranscription Factorsandrogen receptorcastration resistanceETV5neuroendocrine prostate cancerobeticholic acid

Identifiers

PMID40117308
PMCPMC11962414

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.