Evidence map›Paper›PMID 40117303›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

High-density CRISPRi screens reveal diverse routes to improved acclimation in cyanobacteria.

Andrew Hren, Nicole Lollini, Dana L Carper, Paul E Abraham, Jeffrey C Cameron, Jerome M Fox, Carrie A Eckert

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrew HrenDepartment of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80304.ORCID 0009-0002-3269-4425
Nicole LolliniDepartment of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80304.
Dana L CarperBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831.
Paul E AbrahamBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831.ORCID 0000-0003-2685-9123
Jeffrey C CameronDepartment of Biochemistry, University of Colorado, Boulder, CO 80309.ORCID 0000-0002-6630-8345
Jerome M FoxDepartment of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80304.ORCID 0000-0002-3739-1899
Carrie A EckertBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831.ORCID 0000-0003-4201-2926

Funding

DOD | USA | AFC | CCDC | Army Research Office (ARO) W911NF-18-1-0159U.S. Department of Energy (DOE) DE-SC0018368
6 · The paper itself

Abstract

Cyanobacteria are the oldest form of photosynthetic life on Earth and contribute to primary production in nearly every habitat, from permafrost to hot springs. Despite longstanding interest in the acclimation of these microbes, it remains poorly understood and challenging to rewire. This study uses a high-density, genome-wide CRISPR interference screen to examine the influence of gene-specific transcriptional variation on the growth of

Indexed as

AcclimatizationClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsCyanobacteriaSynechococcusBacterial ProteinsGene Expression Regulation, BacterialPhotosynthesisBacterial Proteinsenergy transductionenvironmental acclimationgenome-wide screensphotosynthesisspectral tuning

Identifiers

PMID40117303
PMCPMC11962424

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.