ReviewChemistry & biodiversity2025
Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014-2023).
Review in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Ultrasound-Assisted Deep Eutectic Solvent Extraction of Total Alkaloids fromMolecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ecosystem interactions. Among these products, plant-derived alkaloids are bioactive compounds of significant pharmacological interest, traditionally extracted using conventional solvents known for their environmental and health hazards. Historically, alkaloid extraction relied on acid-base methods, which separate these compounds based on their solubility under different pH conditions. Since the 19th century, extraction techniques have evolved from traditional methods to modern approaches such as supercritical fluid extraction (SFE), microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), and the use of ionic liquids (ILs) and deep eutectic solvents (DESs). These advanced methods optimize yield, reduce extraction times, and enhance sustainability by minimizing solvent use and environmental impact. This review explores the evolution of alkaloid extraction methodologies from 2014 to 2023, emphasizing eco-friendly techniques. It discusses the principles and applications of SFE, MAE, UAE, ILs, and DESs in extracting alkaloids from plants, highlighting their pivotal role in modern natural product chemistry. These advancements underscore ongoing efforts to develop efficient and sustainable practices in alkaloid extraction, which is essential for pharmaceutical and medicinal applications.
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Registered trials
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