Evidence map›Paper›PMID 40117093›Full record

ArticleMolecular diversity2025

Synthesis of xanthenone fused spiro pyrrolidine oxindoles via multicomponent [3 + 2] cycloaddition reactions.

Gurusivam Paramasivam, Baskaralingam Palanichamy, Nagaraaj Paramathevar

Abstract read
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In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gurusivam ParamasivamDepartment of Chemistry, College of Engineering, Anna University, Guindy, Chennai, 600025, India.
Baskaralingam PalanichamyDepartment of Chemistry, College of Engineering, Anna University, Guindy, Chennai, 600025, India.
Nagaraaj ParamathevarDepartment of Chemistry, College of Engineering, Anna University, Guindy, Chennai, 600025, India. nagaiitd@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Xanthenone fused spiro-pyrrolidine oxindoles were conveniently synthesized in good yields with high regio- and diastereoselectivity from a multicomponent synthesis involving tetrahydroxanthenones, α-amino acids, and isatins via an azomethine ylide based [3 + 2] cycloaddition process. We utilized tetrahydroxanthenone as a dipolarophile for the first time in the [3 + 2] cycloaddition of decarboxylated azomethine ylide. The relative configuration of the spirocycloadduct was determined by single-crystal X-ray diffraction analysis.

Indexed as

Cycloaddition ReactionOxindolesPyrrolidinesSpiro CompoundsAzo CompoundsCrystallography, X-RayModels, MolecularMolecular StructureStereoisomerismThiosemicarbazones2-oxindoleAzo CompoundsazomethineOxindolespyrrolidinePyrrolidinesSpiro CompoundsThiosemicarbazonesAzomethine ylideCycloadditionFused spiro heterocyclesMulticomponent reactionOxindolesPyranopyrrolidineTetrahydroxanthenone

Identifiers

PMID40117093

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.