Evidence map›Paper›PMID 40117029›Full record

ArticleBiological trace element research2025

Inflammation May Mediate the Effects of Fluoride on Liver and Kidney Function of Adults: Cross-Sectional Studies in China.

Minghao Geng, Yi Cheng, Leizhen Duan, Guangshen Dong, Shuo Yang, Xuecheng Jiao, Weihua Jia, Hui Huang, Ming Dou, Xiaoli Fu and 4 more

Abstract read
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Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Minghao GengDepartment of Preventive Medicine, School of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Yi ChengDepartment of Environmental Health & Environment and Health Innovation Team, School of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Leizhen DuanZhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, 450001, Henan, China.
Guangshen DongDepartment of Basic Medicine, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Shuo YangDepartment of Environmental Health & Environment and Health Innovation Team, School of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Xuecheng JiaoDepartment of Endemic Diseases, Puyang Center for Disease Control and Prevention, Puyang, 457005, Henan, China.
Weihua JiaDepartment of Endemic Diseases, Zhengzhou Center for Disease Control and Prevention, Zhengzhou, 450006, Henan, China.
Hui HuangDepartment of Environmental Health & Environment and Health Innovation Team, School of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Ming DouSchool of Water Conservancy and Transportation, School of Ecology and Environment, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Xiaoli FuDepartment of Preventive Health Care, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Fangfang YuDepartment of Environmental Health & Environment and Health Innovation Team, School of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Yuhui DuNational Experimental Teaching Demonstration Center of Public Health and Preventive Medicine, School of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China. duyuhui@zzu.edu.cn.
Guoyu ZhouDepartment of Environmental Health & Environment and Health Innovation Team, School of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China. zhouguoyu@zzu.edu.cn.
Yue BaDepartment of Environmental Health & Environment and Health Innovation Team, School of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To assess associations among fluoride exposure, the inflammation, and liver and kidney functions, a total of 1646 adults aged ≥ 18 years were recruited in cross-sectional studies conducted in 2017 and 2022 in fluorosis areas. Questionnaire surveys were administered to obtain the demographic information. Urine and blood samples were collected for determinations of urinary fluoride (UF), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBIL), blood urea nitrogen (BUN), serum creatinine (SCr), serum uric acid (SUA), and white blood cell (WBC) counts. Linear regressions, generalized linear models, and mediation analyses were employed here. We found that AST, BUN, and SUA increased by 0.589, 0.087, and 4.226 with a 1 mg/L increment of UF, and the SCr showed a negative linear association with UF (β =  - 0.790) in all. Similar results were also observed in female. However, we only found the positive linear association between UF and AST/ALT in male. We also detected a significant modification by gender on associations between UF and values of AST, ALT, BUN, and SCr. Besides, participants with higher UF levels had higher counts of monocytes (β = 0.014) and neutrophils (β = 0.147) both in all and in stratified analyses of gender. Associations between AST/ALT, TBIL, SCr, SUA, and counts of WBC were revealed. In addition, there were mediator effects of monocytes and neutrophils in associations between UF and BUN (or SUA). We observed similar results in the age group of 46-64 years with those in all participants. This study observed a statistically significant association between UF and adult levels of AST, SCr, BUN, SUA, as well as monocyte and neutrophil counts, particularly in females. Furthermore, alterations in monocyte and neutrophil counts partially mediate the association between UF and BUN (or SUA). Our findings reveal the effects of fluoride exposure on liver and kidney function and provide clues for analyzing the relevant mechanism from an inflammatory perspective.

Indexed as

FluoridesInflammationKidneyLiverAdultAgedAspartate AminotransferasesChinaCross-Sectional StudiesFemaleHumansMaleMiddle AgedUric AcidYoung AdultAspartate AminotransferasesFluoridesUric AcidAdultFluorideKidneyLiverWhite blood cells

Identifiers

PMID40117029

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.