Evidence map›Paper›PMID 40117005›Full record

ArticleNeurosurgical review2025

Risk factors for bleeding in patients with arteriovenous malformations associated with intracranial aneurysms.

Nebojsa Lasica, Hanah Hadice Gull, Ulrich Sure, Petar Vulekovic, Djula Djilvesi, Dragan Andjelic, Ramazan Jabbarli, Cornelius Deuschl, Marvin Darkwah Oppong

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nebojsa Lasica *Clinic of Neurosurgery, University Clinical Center of Vojvodina, Novi Sad, Serbia. nebojsa.lasica@mf.uns.ac.rs.ORCID http://orcid.org/0000-0002-4600-7756
Hanah Hadice Gull *Department of Neurosurgery and Spine Surgery, University Hospital, University of Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-0483-4243
Ulrich SureDepartment of Neurosurgery and Spine Surgery, University Hospital, University of Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-9073-1821
Petar VulekovicClinic of Neurosurgery, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Djula DjilvesiClinic of Neurosurgery, University Clinical Center of Vojvodina, Novi Sad, Serbia.ORCID http://orcid.org/0000-0003-3131-7855
Dragan AndjelicCenter for Radiology, University Clinical Center of Vojvodina, Novi Sad, Serbia.ORCID http://orcid.org/0009-0001-3034-2509
Ramazan JabbarliDepartment of Neurosurgery and Spine Surgery, University Hospital, University of Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-8356-6629
Cornelius DeuschlDepartment of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0001-9262-7289
Marvin Darkwah OppongDepartment of Neurosurgery and Spine Surgery, University Hospital, University of Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0003-1021-5024

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesNatural history of brain arteriovenous malformations (bAVMs) with associated intracranial aneurysms (IAs) reveals a higher rate of hemorrhage. We aimed to identify the prevalence and risk factors for hemorrhage in a subgroup of patients with bAVMs and associated arterial IAs.

methodsThe authors conducted an international, bicentric retrospective study of patients with ruptured and unruptured bAVMs with associated IAs treated at tertiary centers between January 2013 and December 2022. Sociodemographic data, clinical characteristics, and radiological parameters in patients with bAVM and associated IAs were analyzed.

resultsOf 944 patients with bAVM, 137 individuals with 191 associated arterial IAs were included in the final analysis. Bleeding presentation was documented in 85 cases (62.0%). The mean size of bAVM-associated IAs was 6.8 (SD = 4.8) mm. Multiple intracranial aneurysms (MIA) were present in 35 patients (25.5%). bAVM-associated IAs were classified as nidal in 19.0%, flow-related in 73.7%, and unrelated in 7.3% of cases. Univariate analysis revealed that arterial hypertension (odds ratio 4.37 [CI 1.52-12.57]; P =.004), history of smoking (odds ratio 5.77 [CI 1.26-26.53]; P =.013), and high-grade bAVMs (grades IV/V, odds ratio 0.35 [CI 0.15-0.87]; P =.02), were associated with a bleeding risk. In the multivariable analysis, only arterial hypertension remained significantly associated with the bleeding event (adjusted odds ratio 3.37 [CI 1.07-10.58]; P =.038).

conclusionsObservational data from our large bicentric cohort of patients with bAVM and associated IAs identified arterial hypertension as a risk factor associated with an increased risk of bleeding.

trial registrationThe study was approved by the Institutional Review Board (IRB) of the University Clinical Center of Vojvodina and the University of Duisburg-Essen (20-9288-BO).

Indexed as

Intracranial AneurysmIntracranial Arteriovenous MalformationsAdultAgedAneurysm, RupturedFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsArteriovenous malformationAssociated aneurysmBleedingRisk factors

Identifiers

PMID40117005

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.