Identification of Bioactive Compounds from Citri Reticulatae Pericarpium and Evaluation of Their Uric Acid-Lowering Activity.

Jiahao Yuan, Daren Wu, Jiang Liu, Hangran Yang, Yingjian Su, Lingyu Zhang, Shan Lin, Zhixia Zhao, Feng Kang, Jian Li

Abstract read

In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Food science & nutrition · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiahao Yuan *College of Food and Biological Engineering, Jimei University, No.43, Yindou Rd, Xiamen City, Fujian Province, China.

Daren Wu *College of Food and Biological Engineering, Jimei University, No.43, Yindou Rd, Xiamen City, Fujian Province, China.

Jiang LiuCollege of Food and Biological Engineering, Jimei University, No.43, Yindou Rd, Xiamen City, Fujian Province, China.

Hangran YangCollege of Food and Biological Engineering, Jimei University, No.43, Yindou Rd, Xiamen City, Fujian Province, China.

Yingjian SuCollege of Food and Biological Engineering, Jimei University, No.43, Yindou Rd, Xiamen City, Fujian Province, China.

Lingyu ZhangCollege of Food and Biological Engineering, Jimei University, No.43, Yindou Rd, Xiamen City, Fujian Province, China.

Shan LinCollege of Food and Biological Engineering, Jimei University, No.43, Yindou Rd, Xiamen City, Fujian Province, China.

Zhixia ZhaoInstitute of Agro-Food Storage and Processing, Xinjiang Academy of Agricultural Sciences, Urumqi, 830091, Xinjiang, China.

Feng KangInstitute of Agro-Food Storage and Processing, Xinjiang Academy of Agricultural Sciences, Urumqi, 830091, Xinjiang, China.

Jian LiCollege of Food and Biological Engineering, Jimei University, No.43, Yindou Rd, Xiamen City, Fujian Province, China. lijian2013@jmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Citri Reticulatae Pericarpium, the dried and mature peel of wild Citrus reticulata Blanco and its cultivated varieties in the rutaceae family, is an important herb and condiment in Chinese medicine. At present, there are few relevant reports, especially in-depth reports, on the discovery of effective anti-gout natural products from CRP. In this study, four compounds were extracted and characterized from CRP using 70% ethanol, RP-C18, thin layer chromatography (TLC), Sephadex LH-20, high performance liquid chromatography (HPLC), and nuclear magnetic resonance spectroscopy (NMR). Additionally, monomer compounds (apigenin, luteolin) in CRP, along with those isolated from CRP, were investigated through molecular docking and in vitro assessment of their XOD inhibitory activity. Notably, the lowest binding energy (-10.3 kcal/mol) and IC

Indexed as

CitrusGout SuppressantsPlant ExtractsUric AcidAnimalsCell LineFruitMolecular Docking SimulationRatsXanthine OxidaseGout SuppressantsPlant ExtractsUric AcidXanthine OxidaseBioactive compoundsCitri Reticulatae PericarpiumMolecular dockingUric acid-lowering activityXOD

Identifiers

PMID40117004

DOI10.1172/JCI40124

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.