ArticleJournal of neuro-oncology2025
Early and late structural brain changes after radiation therapy: an MRI study in glioma patients.
Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A Real-Time Cell Image Segmentation Method Based on Multi-Scale Feature Fusion.Bioengineering (Basel, Switzerland) · 2025Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGiven the increasing survival rate of patients with brain tumors, it is relevant to investigate the relationship between radiation dose and the severity of lesions in healthy tissue. This study evaluated the effects of radiotherapy (RT) on healthy brain tissue in glioma patients using quantitative magnetic resonance imaging (MRI) to identify radiation-sensitive brain regions and support personalized RT strategies.
methodsA retrospective analysis included 75 MRIs from 25 patients (Group A) and 39 MRIs from 13 patients (Group B). All underwent postoperative RT with doses ranging from 25 to 60 Gy. MRIs were collected multiple times: before RT, up to 8 months post-RT (Group A), and between 9 and 16 months post-RT (Group B). A linear mixed-effects model identified predictors of volume reduction, cortical thinning, and increased apparent diffusion coefficient (ADC) after RT.
resultsSignificant ADC increases were observed in the hemisphere ipsilateral to the tumor site after RT, in the cuneus, inferior parietal, paracentral, pericalcarine, parahippocampal, precuneus, and superior parietal cortices. When controlling for the confounding factors (sex, age, tumor type, scanner, imaging interval, total dose, and regional dose), ADC changes correlated with dose in contralateral middle temporal, par opercularis, and lingual gyri.
conclusionsBrain volume reduction, cortical thinning, and, mainly, ADC increase were observed in healthy brain regions, indicating potential treatment sequelae. These findings emphasize the importance of developing neuroprotective strategies for radiation-sensitive brain regions and individualized treatment approaches to mitigate cognitive and functional impacts, enhancing patient care and quality of life.
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Registered trials
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