Evidence map›Paper›PMID 40116971›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

The association between allostatic load and lymphedema in breast cancer survivors.

Barnabas Obeng-Gyasi, Yevgeniya Gokun, Mohamed I Elsaid, J C Chen, Barbara L Andersen, William E Carson, Sachin Jhawar, Jesus D Anampa, Dionisia Quiroga, Roman Skoracki and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Barnabas Obeng-GyasiIndiana University School of Medicine, Indianapolis, IN, USA.
Yevgeniya GokunCenter for Biostatistics, College of Medicine, The Ohio State University, Columbus, OH, USA.
Mohamed I ElsaidCenter for Biostatistics, College of Medicine, The Ohio State University, Columbus, OH, USA.
J C ChenDivision of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, OH, USA.
Barbara L AndersenDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
William E CarsonDivision of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, OH, USA.
Sachin JhawarDepartment of Radiation Oncology, The Ohio State University, Columbus, OH, USA.
Jesus D AnampaDepartment of Medical Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Dionisia QuirogaDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Roman SkorackiDivision of Reconstructive Oncologic Plastic Surgery, Department of Plastic Surgery, The Ohio State University, Columbus, OH, USA.
Samilia Obeng-GyasiDivision of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, OH, USA. samilia.obeng-gyasi@osumc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAllostatic load, a measure of physiological dysregulation secondary to chronic exposure to socioenvironmental stressors, is associated with 30-day postoperative complications and mortality in patients with breast cancer. This study aimed to examine the association between allostatic load (AL) at diagnosis and development of breast cancer-related lymphedema (BCRL).

methodsPatients aged 18 years or older who received surgical treatment for stage I-III breast cancer between 2012 and 2020 were identified from The Ohio State University Cancer Registry. AL was calculated using biomarkers from the cardiovascular, metabolic, renal, and immunologic systems. A high AL was defined as AL > median. Logistic regression analyses examined the association between AL and BRCL, adjusting for sociodemographic, clinical, and treatment factors.

resultsAmong 3,609 patients, 18.86% (n = 681) developed lymphedema. A higher proportion of patients with lymphedema were Black (11.89% vs. 7.38%, p < 0.0001), Medicaid insured (12.19% vs. 6.97%, p < 0.0001), had stage 3 disease (7.05% vs. 1.57%, p < 0.0001), and had a high AL (53.63% vs. 46.90%, p = 0.0018). In adjusted analysis, high AL was associated with higher odds of developing lymphedema than low AL (OR 1.281 95% CI 1.06-1.55). Moreover, a 1-unit increase in AL was associated with 10% higher odds of lymphedema (OR 1.10, 95% CI 1.04-1.16). There was no statistically significant association between AL and severity of lymphedema (OR 1.02, 95% CI 0.82-1.23).

conclusionIn this retrospective cohort of breast cancer survivors, high AL at diagnosis was associated with higher odds of developing lymphedema. Future research should elucidate the pathways by which AL influences lymphedema.

Indexed as

AllostasisBreast Cancer LymphedemaBreast NeoplasmsCancer SurvivorsLymphedemaAdultAgedFemaleHumansMiddle AgedNeoplasm StagingOhioRetrospective StudiesRisk FactorsAllostatic loadBreast cancerLymphedemaStressSurvivorship

Identifiers

PMID40116971
PMCPMC11928421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.