ArticleOrganic letters2025
Unlocking the Phosphoric Acid Catalyzed Asymmetric Transfer Hydrogenation of 2-Alkenyl Quinolines for Efficient Flow Synthesis of Hancock Alkaloids.
Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Chiral tetrahydroquinolines are present in several bioactive molecules, such as the Hancock alkaloids. Although the organocatalytic asymmetric transfer hydrogenation of 2-aryl quinolines has emerged as a safer alternative to using hydrogen gas, analogous reactions with 2-alkenyl quinolines remain unexplored. Here we present a protocol to synthesize key enantioenriched intermediates to the Hancock alkaloids, providing a constant outcome for, at least, a 24 h continuous flow operation.
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