Evidence map›Paper›PMID 40116680›Full record

ArticleJournal of Alzheimer's disease : JAD2025

A preliminary study on plasma markers across cognitive stages and links to a history of mild traumatic brain injury.

Christian LoBue, Barbara E Stopschinski, Nil Saez Calveras, Amber Salter, Doug Galasko, Chris Giza, C Munro Cullum, Peter M Douglas, John Hart

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christian LoBueDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-9671-5526
Barbara E StopschinskiPeter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-5715-4567
Nil Saez CalverasDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-9153-9700
Amber SalterPeter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1088-110X
Doug GalaskoDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-6195-3241
Chris GizaDepartment of Pediatrics, University of California, Los Angeles, CA, USA.ORCID 0000-0002-5721-2667
C Munro CullumDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-9706-5465
Peter M DouglasDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-0734-1049
John HartDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-3919-8125

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAMES B BREWER · 2019 to 2026
$34.9M
Lipid sensing through G protein geranylgeranylationR01AG076529 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI Peter Mahan Douglas · 2022 to 2026
$1.7M
Heat Shock Factor mediates actin phosphorylation in tissue integrity and ageR01AG061338 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI DOUGLAS, PETER MAHAN · 2019 to 2023
$1.7M
Multimodal regulation of intracellular lipid surveillanceR01GM153859 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Peter Mahan Douglas · 2024 to 2026
$1.1M
Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History (PATH)K23AG075261 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI Christian Barrett LoBue · 2022 to 2026
$675k
NIA NIH HHS K23 AG075261NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG061338NIA NIH HHS R01 AG076529NIGMS NIH HHS R01 GM153859
6 · The paper itself

Abstract

Potential implications of a history of mild traumatic brain injury (mTBI) during aging are understudied. Seven plasma markers were measured in matched participants having normal cognition, mild cognitive impairment (MCI) and dementia of the Alzheimer's type (DAT) with and without a history of mTBI. Phosphorylated tau

Indexed as

Alzheimer DiseaseBrain ConcussionCognitive DysfunctionAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersFemaleHumansMaleMiddle AgedNeurofilament ProteinsNeuropsychological TestsPeptide Fragmentstau ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)Biomarkersneurofilament protein LNeurofilament ProteinsPeptide Fragmentstau ProteinsAlzheimer's diseaseblood biomarkerbrain injurycognitive dysfunctionconcussiondementia of the Alzheimer's typetau

Identifiers

PMID40116680
PMCPMC12055478

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.