ArticleVeterinary medicine and science2025
Ebselen Alleviates Sepsis-Induced Acute Kidney Injury by Regulating Endoplasmic Reticulum Stress, Apoptosis, and Oxidative Stress.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A multimodal predictive model incorporating transcriptomic-guided blood biomarkers and clinical variables for sepsis-associated acute kidney injury.Renal failure · 2026Article
- GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review).International journal of molecular medicine · 2026Review
- Sinapic Acid Attenuates LPS-Induced Acute Kidney Injury in Rats: Changes in Autophagy-Related, Apoptotic, Inflammatory, and Oxidative Stress Markers.Journal of biochemical and molecular toxicology · 2026Article
- Crosstalk of regulated cell death pathways in sepsis-associated acute kidney injury: implications for therapy.Frontiers in cell and developmental biology · 2026Review
- Hyperin attenuates cerulein-induced acute pancreatitis by regulating inflammation and oxidative stress.Journal of molecular histology · 2025Article
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Authors and funding
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Abstract
Acute kidney injury (AKI) is one of the most serious complications of sepsis, with substantial morbidity and mortality, and no effective treatment exists. Ebselen is of pharmacological significance in the treatment and prevention of a variety of human diseases, such as cancer and cardiovascular disorders. Nevertheless, the role of Ebselen in the pathogenesis of sepsis-induced AKI remains unknown. Therefore, we aimed to elucidate the impact of Ebselen, an active seleno-organic compound, on AKI induced by lipopolysaccharide (LPS) and the associated molecular mechanisms, including endoplasmic reticulum (ER) stress, apoptosis, and oxidative stress. We established the sepsis-induced AKI rat model by injecting 5 mg/kg of LPS intraperitoneally. The rats were given Ebselen (5 and 10 mg/kg, orally) before receiving the LPS injection. Ebselen treatment alleviated renal tubular injury and reduced the levels of blood urea nitrogen (BUN) and creatinine (CREA) in LPS-induced sepsis model. Immunohistochemical and terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) analyses revealed that Ebselen reduced caspase-3 expressions and apoptotic cells triggered by LPS in kidney tissues. LPS-induced sepsis caused ER stress, and Ebselen treatment alleviated the ER stress by regulating eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) and GRP78 in kidney tissue, as well as activating transcription factor 4 (ATF4) and activating transcription factor 6 (ATF6) in serum. Ebselen decreased malondialdehyde (MDA) levels induced by LPS. Ebselen alleviated LPS-induced oxidative stress by modulating MDA and superoxide dismutase (SOD) levels in kidney tissues and SOD, glutathione peroxidase (GPx) and serum total antioxidant status (TAS) levels in serum. In conclusion, we report for the time that Ebselen might alleviate sepsis-induced AKI through the regulation of ER stress apoptosis and oxidative stress.
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