ArticleVeterinary medicine and science2025
The Interaction of Ocimum basilicum, Perilla frutescens and Mentha spicata Essential Oils With Norfloxacin Against Antibiotic-Resistant Salmonella Spp. That Cause Disease in Chickens.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Changes in the properties of Mentha spicata L. essential oil under the influence of soil characteristics, available water, and altitude in the mountainous regions of Kashan.BMC plant biology · 2026Article
- Green Synthesis ofAnti-cancer agents in medicinal chemistry · 2026Article
- Review
- Review
- Synergistic effects ofFrontiers in antibiotics · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe misuse of antibiotics in livestock farming has led to the emergence of antibiotic-resistant bacteria, which pose a serious threat to global animal and human health. Essential oils extracted from the leaves of Ocimum basilicum, Perilla frutescens and Mentha spicata contain bioactive compounds with bactericidal properties.
objectivesThis study aimed to evaluate the bactericidal activity of Ocimum basilicum, Perilla frutescens and Mentha spicata essential oils and their combination with the antibiotic norfloxacin, against antibiotic-resistant Salmonella spp. isolated from diseased chickens.
methodsThe antibiotic susceptibility testing of the isolated bacteria was conducted using the disc diffusion method. The bactericidal efficacy of essential oils and antibiotics was assessed by determining the minimum bactericidal concentration. The interaction between essential oils and antibiotics was analysed using the fractional bactericidal concentration index through the microdilution chequerboardtechnique.
resultsSalmonella typhimurium and Salmonella enteritidis were recovered from the organs of infected chickens. Isolated Salmonella spp. displayed significant resistance to amoxicillin, ampicillin, streptomycin and cefuroxime. The essential oils of Ocimum basilicum and Mentha spicata demonstrated similar minimum bactericidal concentration (MBC) values of 8,000 µg/mL, while the essential oil of Perilla frutescens showed a higher MBC value of 10,000 µg/mL. Analysis of the interaction between these essential oils and norfloxacin indicated that both Ocimum basilicum and Mentha spicata exhibited a synergistic effect, whereas Perilla frutescens exhibited an additive effect when combined with norfloxacin in eradicating Salmonella spp.
conclusionThe study concluded that combining essential oils from three herbs with the antibiotic norfloxacin was highly effective in fighting antibiotic-resistant Salmonella spp. isolated from infected chickens.
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